Riso L P, Klein D N, Anderson R L, Ouimette P C
Department of Psychology, Georgia State University, Atlanta 30303, USA.
J Pers Disord. 2000 Fall;14(3):208-17. doi: 10.1521/pedi.2000.14.3.208.
While several studies have examined psychiatric disorders in the relatives of individuals with borderline personality disorder, many of these studies have not employed a family study methodology and suffer from other methodological shortcomings. Thus, the conclusions from family data addressing the validity of borderline personality disorder, its relation to other conditions, and its distinction from mood disorders, continue to be debated. The present investigation employed a family study design with direct interviews with relatives, structured diagnostic interviews with both probands and relatives, and blind assessment of relatives. Rates of psychiatric disorders were examined in 563 relatives of outpatients with mood disorders (n = 119), 54 relatives of outpatients with borderline personality disorder and no history of mood disorder (n = 11), and 229 relatives of never psychiatrically ill controls (n = 45). Results indicate increased rates of mood disorders and personality disorders in the relatives of borderline probands compared with never psychiatrically ill controls. Familial aggregation of psychiatric disorders was generally similar for borderline personality and the mood disorder comparison group. The results suggest there may be common etiological factors between borderline personality disorder and mood disorders.
虽然有几项研究调查了边缘型人格障碍患者亲属中的精神障碍，但其中许多研究并未采用家族研究方法，且存在其他方法学上的缺陷。因此，关于边缘型人格障碍的有效性、其与其他病症的关系以及与心境障碍的区别等家族数据得出的结论仍存在争议。本研究采用家族研究设计，直接对亲属进行访谈，对先证者和亲属进行结构化诊断访谈，并对亲属进行盲法评估。研究了563名心境障碍门诊患者的亲属（n = 119）、54名无心境障碍病史的边缘型人格障碍门诊患者的亲属（n = 11）以及229名从未患过精神疾病的对照者的亲属（n = 45）中的精神障碍发生率。结果表明，与从未患过精神疾病的对照者相比，边缘型先证者的亲属中心境障碍和人格障碍的发生率更高。边缘型人格障碍和心境障碍比较组的精神障碍家族聚集情况总体相似。结果表明，边缘型人格障碍和心境障碍之间可能存在共同的病因因素。
