Pal J K, Sarino W A
Department of Psychiatry, Mt. Sinai Hospital, Chicago, IL, USA.
Psychosom Med. 2000 Sep-Oct;62(5):736-8. doi: 10.1097/00006842-200009000-00018.
The case of a psychotic woman is described in which risperidone use was found to correspond with an increase in the size of a prolactinoma and prevented the return of serum prolactin level to baseline.
Although the patient had been treated with a high dose of bromocriptine, her prolactin level remained elevated, causing persistent galactorrhea. The patient later was treated with olanzapine and carbamazepine successfully.
This case report highlights the role of risperidone on prolactin and discusses alternative methods of treating psychosis when the etiology is unclear, especially in younger patients.
The authors recommend that additional studies regarding the relationship between the growth of prolactinoma and atypical antipsychotics would be worthwhile.
描述一名患有精神病的女性病例，该病例中发现使用利培酮与催乳素瘤大小增加相关，并阻止血清催乳素水平恢复至基线。
尽管患者接受了高剂量的溴隐亭治疗，但其催乳素水平仍居高不下，导致持续性溢乳。该患者随后成功接受了奥氮平和卡马西平治疗。
本病例报告强调了利培酮对催乳素的作用，并讨论了病因不明时治疗精神病的替代方法，尤其是在年轻患者中。
作者建议，关于催乳素瘤生长与非典型抗精神病药物之间关系的更多研究将是有价值的。
