Schlosser R J, Spotnitz W D, Peters E J, Fang K, Gaston B, Gross C W
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health Sciences Center, USA.
Otolaryngol Head Neck Surg. 2000 Oct;123(4):357-62. doi: 10.1067/mhn.2000.107405.
Decreased exhaled nitric oxide (NO) is found in chronic sinusitis. NO metabolites (nitrates, nitrites, and S-nitrosothiols) were measured in sinus lavages with a rabbit model of chronic sinusitis. NO metabolite levels (mean +/- SD) were 3.0+/-1.6 micromol/L in uninfected rabbits, 10.7+/-11.4 micromol/L in infected animals, and 7.6+/-5.4 micromol/L in postantrostomy recovering animals. Infected sinuses had elevated levels of NO metabolites that were statistically significant (P<0.01) when compared with uninfected sinuses. Mucociliary transport velocity was measured in uninfected (16.0+/-5.7 mm/minute), infected (5.2+/-1.3 mm/minute), and recovery phases (3.0 mm/minute). Endoscopic appearance, light and electron microscopy, and bacterial cultures improved during recovery. Elevated levels of NO metabolites were found during chronic sinusitis and began to return to normal levels during recovery. The possible link between NO in epithelial autotoxicity and host defense mechanisms warrants further investigation.
慢性鼻窦炎患者呼出的一氧化氮（NO）水平降低。在慢性鼻窦炎的兔模型中，对鼻窦灌洗液中的NO代谢产物（硝酸盐、亚硝酸盐和S-亚硝基硫醇）进行了测量。未感染兔子的NO代谢产物水平（平均值±标准差）为3.0±1.6微摩尔/升，感染动物为10.7±11.4微摩尔/升，鼻窦造口术后恢复动物为7.6±5.4微摩尔/升。与未感染的鼻窦相比，感染鼻窦的NO代谢产物水平升高，具有统计学意义（P<0.01）。在未感染（16.0±5.7毫米/分钟）、感染（5.2±1.3毫米/分钟）和恢复阶段（3.0毫米/分钟）测量了黏液纤毛运输速度。恢复过程中，内镜表现、光镜和电镜检查以及细菌培养均有所改善。慢性鼻窦炎期间发现NO代谢产物水平升高，恢复期间开始恢复到正常水平。上皮细胞自毒性中的NO与宿主防御机制之间的可能联系值得进一步研究。
