Kim I A, Nosulia E V
Vestn Otorinolaringol. 2010(4):78-81.
This study included 20 patients presenting with polypous rhinosinusitis examined before and after endoscopic intervention in the nasal cavity and paranasal sinuses. Nitric oxide (NO) content in nasal secretion and polypoid tissue was estimated from the concentration of nitrates that, together with nitrites, are the final products of oxidation of nitric oxide and serve as markers of endogenous NO. Nitrates in the nasal secretion, endonasal mucosa, and polypous tissue were determined by the ionometric technique. Their content was additionally measured in 12 subjects without polypous rhinosinusitis. The nasal secretion and polypous tissue of PRS patients were found to contain nitrates at a higher concentration compared with healthy subjects. Nitrate concentrations in the nasal secretion and polypous tissue of PRS patients were not significantly different. Mean saccharine transport time in the nasal cavity of the patients with an elevated level of nitrates in the nasal secretion was significantly higher than in PRS patients with the lowered nitrate levels. It means that high concentrations of nitric oxide markers in the nasal secretion and polypous tissue of the patients with polypous rhinosinusitis have negative effect on the efficiency of mucociliary transport. In addition, results of the study confirm the possibility of anti-inflammatory therapy with Erespal (fenspirid) for the correction of inflammatory changes during the postoperative period.
本研究纳入了20例患有息肉性鼻窦炎的患者，在鼻腔和鼻窦进行内镜干预前后对其进行检查。通过测定硝酸盐的浓度来估算鼻分泌物和息肉样组织中的一氧化氮（NO）含量，硝酸盐与亚硝酸盐一起，是一氧化氮氧化的终产物，可作为内源性NO的标志物。采用离子测量技术测定鼻分泌物、鼻内黏膜和息肉样组织中的硝酸盐含量。另外在12名无息肉性鼻窦炎的受试者中测量了它们的含量。发现息肉性鼻窦炎患者的鼻分泌物和息肉样组织中硝酸盐浓度高于健康受试者。息肉性鼻窦炎患者鼻分泌物和息肉样组织中的硝酸盐浓度无显著差异。鼻分泌物中硝酸盐水平升高的患者鼻腔内平均糖精转运时间显著高于硝酸盐水平降低的息肉性鼻窦炎患者。这意味着息肉性鼻窦炎患者鼻分泌物和息肉样组织中高浓度的一氧化氮标志物对黏液纤毛运输效率有负面影响。此外，研究结果证实了使用艾瑞松（芬司匹利）进行抗炎治疗以纠正术后炎症变化的可能性。
