Butler A R, Rutherford T J, Short D M, Ridd J H
Centre for Biomolecular Sciences, University of St Andrews, Fife, KY16 9ST, Scotland.
Nitric Oxide. 2000 Oct;4(5):472-82. doi: 10.1006/niox.2000.0299.
By the observation of chemically induced dynamic nuclear polarization in (15)N NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even under acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main products are nitrite and nitrate, both produced by a radical pathway, and tyrosine nitration is a minor reaction. It is suggested that tyrosine catalyzes the production of NO()(2) and HO() from peroxynitrite.
通过在（15）N核磁共振光谱中对化学诱导动态核极化的观察表明，即使在酸性条件下，N-乙酰酪氨酸的硝化反应在很大程度上也是一个自由基过程。在酪氨酸与过氧亚硝酸根的碱性反应中，主要产物是亚硝酸盐和硝酸盐，两者均通过自由基途径产生，而酪氨酸硝化是一个次要反应。有人提出酪氨酸催化过氧亚硝酸根产生NO（）（2）和HO（）。
