Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva F F, Deghenghi R, Camanni F, Ghigo E
Department of Internal Medicine, University of Turin, Italy.
J Endocrinol Invest. 2000 Sep;23(8):493-5. doi: 10.1007/BF03343763.
An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently purified from rat and human stomach and named Ghrelin. It has been demonstrated that Ghrelin specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. In this preliminary study, in 4 normal adults [age (mean+/-SE): 28.6+/-3.5 yr; body mass index (BMI): 22.3+/-2.1 kg/m2] we administered 1.0 microg/kg Ghrelin or GHRH-29 to compare their GH-releasing activities in humans. In all subjects Ghrelin induced a prompt, marked and long-lasting increase in circulating GH levels (peak: 107.9+/-26.1 microg/l; AUC: 6503.1+/-1632.7 microg/l/h). The GH response to Ghrelin was clearly higher (p<0.05) than that after GHRH (peak: 22.3+/-4.5 microg/l; AUC: 1517.5+/-338.4 microg/l/h). In conclusion, this preliminary study shows that Ghrelin exerts a strong stimulatory effect on GH secretion in humans releasing more GH than GHRH.
一种生长激素促分泌素受体（GHS-R）的内源性配体最近已从大鼠和人的胃中纯化出来，并被命名为胃饥饿素。已证实，胃饥饿素在体外培养的大鼠垂体细胞以及体内大鼠中均能特异性刺激生长激素的分泌。在这项初步研究中，我们对4名正常成年人[年龄（均值±标准误）：28.6±3.5岁；体重指数（BMI）：22.3±2.1kg/m²]给予1.0μg/kg胃饥饿素或生长激素释放激素-29（GHRH-29），以比较它们在人体中的生长激素释放活性。在所有受试者中，胃饥饿素均能迅速、显著且持久地提高循环生长激素水平（峰值：107.9±26.1μg/l；曲线下面积：6503.1±1632.7μg/l/h）。胃饥饿素引起的生长激素反应明显高于生长激素释放激素（GHRH）后的反应（峰值：22.3±4.5μg/l；曲线下面积：1517.5±338.4μg/l/h，p<0.05）。总之，这项初步研究表明，胃饥饿素对人体生长激素分泌具有强烈的刺激作用，其释放的生长激素比生长激素释放激素更多。
