Xu X J, Hökfelt T, Bartfai T, Wiesenfeld-Hallin Z
Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institutet, S-141 86 Huddinge, Sweden.
Neuropeptides. 2000 Jun-Aug;34(3-4):137-47. doi: 10.1054/npep.2000.0820.
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in sensory and spinal dorsal horn neurons. Endogenous galanin may have an important modulatory function on nociceptive input at the spinal level. In addition, exogenously administered galanin exerts complex effects on spinal nociceptive transmission, where inhibitory action appears to predominate. Peripheral nerve injury and inflammation, conditions associated with chronic pain, upregulate the synthesis of galanin in sensory neurons and spinal cord neurons, respectively. Hence, the sensory effect of galanin may be increased under these conditions, raising the possibility that modulation of the activity of the galanin system may produce antinociception.
甘丙肽是一种由29个或30个（人类）氨基酸组成的肽，存在于感觉神经元和脊髓背角神经元中。内源性甘丙肽可能在脊髓水平对伤害性输入具有重要的调节功能。此外，外源性给予的甘丙肽对脊髓伤害性传递产生复杂的影响，其中抑制作用似乎占主导。外周神经损伤和炎症是与慢性疼痛相关的病症，它们分别上调感觉神经元和脊髓神经元中甘丙肽的合成。因此，在这些情况下甘丙肽的感觉效应可能会增强，这增加了调节甘丙肽系统活性可能产生抗伤害感受的可能性。
