Wiesenfeld-Hallin Z, Bartfai T, Hökfelt T
Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Front Neuroendocrinol. 1992 Oct;13(4):319-43.
The distribution and physiological effects of the neuropeptide galanin (GAL) have been examined in the somatosensory system. GAL is normally present in a few sensory neurons that terminate in the dorsal horn of the spinal cord and it is colocalized with substance P and calcitonin gene-related peptide. After peripheral nerve section, but not dorsal root section, the amount of GAL produced and present in sensory fibers proximal to the section is dramatically upregulated. In parallel functional studies, we could demonstrate that exogenous GAL has a complex effect on the spinal cord reflex excitability, facilitatory at low doses and inhibitory at high doses. Furthermore, GAL inhibits the effect of excitatory neuropeptides physiologically released at the peripheral and central terminals of small diameter afferents that subserve a nociceptive function. After axotomy, the inhibitory effect of GAL is increased. We conclude that GAL may have an important role in the control of nervous impulses that underlie pain states that can occur after peripheral nerve injury.
已对神经肽甘丙肽（GAL）在体感系统中的分布及生理效应进行了研究。GAL通常存在于少数终止于脊髓背角的感觉神经元中，且与P物质和降钙素基因相关肽共定位。在周围神经切断后，而非背根切断后，切断部位近端感觉纤维中产生并存在的GAL量会显著上调。在平行的功能研究中，我们能够证明外源性GAL对脊髓反射兴奋性有复杂影响，低剂量时起促进作用，高剂量时起抑制作用。此外，GAL抑制在小直径传入神经的外周和中枢终末生理性释放的、发挥伤害感受功能的兴奋性神经肽的作用。轴突切断后，GAL的抑制作用增强。我们得出结论，GAL可能在控制外周神经损伤后可能出现的疼痛状态所基于的神经冲动方面发挥重要作用。
