Effects of low-density lipoproteins on blood coagulation and fibrinolytic activity.
作者信息
Azizova O A, Roitman E V, Dement'eva I I, Nikitina N A, Gagaeva E V, Lopukhin Y M
机构信息
Laboratory of Biophysical Basis of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health.
出版信息
Bull Exp Biol Med. 2000 Jun;129(6):541-4. doi: 10.1007/BF02434870.
PMID:11022243
Abstract
In vitro experiments showed that copper-oxidized low-density lipoproteins activate factors of the prothrombin complex in the whole blood and inhibit fibrin generation in both blood and plasma. Moreover, oxidized low-density lipoproteins inhibit fibrinolysis and impair the structure of fibrin clot, which results in hypercoagulation.
摘要
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