Deviatkina T A, Vazhnichaia E M, Lytsenko R V
State Medical Stomatological Academy, Poltava, Ukraine.
Eksp Klin Farmakol. 2000 Jul-Aug;63(4):38-41.
The process of lipid peroxidation (LPO), the activity of antioxidant enzymes, and the effects of piracetam (300 mg/kg) and cerebrolysin (0.1 ml/kg) were studied in the brain, liver, thymus, spleen, and blood serum of white male rats under acute stress (immobilization) conditions. The results of analyses confirmed that the stress syndrome development involves the LPO acceleration and retardation stages not coinciding in various tissues. The antioxidant effect of the nootropic agents in CNS has a permanent character, being independent of the initial status of the animal organism. The effect of both drugs upon the LPO level in peripheral tissues has a modulative character and can be considered as a sum of the central antistressor action and the direct influence upon the functional activity of effectors.
在急性应激（固定）条件下，对白雄性大鼠的脑、肝、胸腺、脾和血清中的脂质过氧化（LPO）过程、抗氧化酶活性以及吡拉西坦（300mg/kg）和脑蛋白水解物（0.1ml/kg）的作用进行了研究。分析结果证实，应激综合征的发展涉及LPO加速和延缓阶段，这些阶段在不同组织中并不一致。促智药在中枢神经系统中的抗氧化作用具有持久性，与动物机体的初始状态无关。两种药物对外周组织中LPO水平的影响具有调节性，可被视为中枢抗应激作用与对效应器功能活性的直接影响之和。
