Iskra R Ia, Ianovych V G
Ukr Biokhim Zh (1999). 2011 May-Jun;83(3):91-8.
The data on the influence of chromium in different tissues of rats at its consumption with mixed fodder in the form of CrCl3 x 6H2O on the intensity of peroxidation processes and activity of antioxidant enzymes are presented. The degree of high chromium content in the studied tissues of rats at its addition to mixed fodder in the amount of 200 microg/kg during 30 days was established. Chromium content in the rat tissues decreased in the order: the spleen, heart, kidneys, lungs, brain, liver, skeletal muscle. In all tissues of rats fed with mixed fodder with chromium addition, except for skeletal muscles, content of lipid peroxidation products--hydroperoxide and TBARS-products decreased. The content of lipid peroxidation products decreased in the spleen, kidneys, liver and lungs. Also in all organs and tissues of rats the activity of glutathione peroxidase, glutathione reductase and catalase increased at the action of chromium. In the brain and kidneys the level of reduced glutathione increased. Superoxide dismutase activity was significantly higher not only in the heart and skeletal muscles of animals and is probably equal in the lungs and liver, and in other organs--the brain, kidneys and spleen in animals of the studied group the enzyme activity was lower as compared to animals of the control group. Obtained results demonstrate the regulatory influence of chromium on free radical process in the rat tissues.
本文给出了大鼠以六水合氯化铬（CrCl₃·6H₂O）形式混于饲料中摄入时，铬对其不同组织过氧化过程强度及抗氧化酶活性影响的数据。确定了在30天内以200微克/千克的量向大鼠混合饲料中添加铬后，大鼠所研究组织中高铬含量的程度。大鼠组织中的铬含量按以下顺序降低：脾脏、心脏、肾脏、肺、脑、肝脏、骨骼肌。在除骨骼肌外的所有添加铬的大鼠混合饲料喂养的组织中，脂质过氧化产物——氢过氧化物和TBARS产物的含量降低。脾脏、肾脏、肝脏和肺中的脂质过氧化产物含量降低。在铬的作用下，大鼠所有器官和组织中的谷胱甘肽过氧化物酶、谷胱甘肽还原酶和过氧化氢酶的活性也增加。脑和肾脏中还原型谷胱甘肽水平升高。超氧化物歧化酶活性不仅在动物的心脏和骨骼肌中显著更高，在肺和肝脏中可能相等，而在其他器官——所研究组动物的脑、肾脏和脾脏中，该酶活性与对照组动物相比更低。所得结果表明铬对大鼠组织中的自由基过程具有调节作用。
