通过在线高效液相色谱-核磁共振联用技术和高效液相色谱-质谱联用技术鉴定乙炔雌二醇的自氧化和光降解产物。
Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-S.
作者信息
Segmuller B E, Armstrong B L, Dunphy R, Oyler A R
机构信息
The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602, USA.
出版信息
J Pharm Biomed Anal. 2000 Oct;23(5):927-37. doi: 10.1016/s0731-7085(00)00363-0.
Abstract
HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified.
摘要
采用高效液相色谱-核磁共振联用仪（HPLC-NMR）、高效液相色谱-质谱联用仪（HPLC-MS）和高效液相色谱-紫外可见分光光度计（HPLC-UV）对乙炔雌二醇（1）主要的溶液自动氧化和光降解产物进行了表征。鉴定出一种氢过氧化物（2）和一系列异构二聚体氧化产物（3 - 7）。
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