• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

对氯苯丙胺或B - 9损伤后大鼠脑区的突触体摄取及5-羟色胺水平

Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions.

作者信息

Massari V J, Sanders-Bush E

出版信息

Eur J Pharmacol. 1975 Sep-Oct;33(2):419-22. doi: 10.1016/0014-2999(75)90190-9.

DOI:10.1016/0014-2999(75)90190-9
PMID:1102320
Abstract

In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are not due to a selective cytotoxic action on B-9 cells; and that a lateral 5HT pathway, possibly from the B-9 cell group, projects to the metathalamus-thalamus.

摘要

与对氯苯丙胺引起的5-羟色胺(5HT)水平显著下降和突触体摄取不同,B-9细胞群的双侧损伤仅引起最小的区域变化,除了丘脑后部-丘脑区域有35%的下降。因此,我们得出结论,对氯苯丙胺的长期生化作用并非由于对B-9细胞的选择性细胞毒性作用;并且一条可能来自B-9细胞群的外侧5HT通路投射至丘脑后部-丘脑。

相似文献

1
Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions.对氯苯丙胺或B - 9损伤后大鼠脑区的突触体摄取及5-羟色胺水平
Eur J Pharmacol. 1975 Sep-Oct;33(2):419-22. doi: 10.1016/0014-2999(75)90190-9.
2
Long-term biochemical and behavioral effects of p-chloroamphetamine in the rat.对氯苯丙胺对大鼠的长期生化及行为影响。
Ann N Y Acad Sci. 1978 Jun 12;305:645-63. doi: 10.1111/j.1749-6632.1978.tb31554.x.
3
Long-term effects of continuous exposure to p-chloroamphetamine on central serotonergic mechanisms in mice.
Biochem Pharmacol. 1978;27(16):2033-7. doi: 10.1016/0006-2952(78)90063-1.
4
Reversible and irreversible phases of serotonin depletion by 4-chloroamphetamine.4-氯苯丙胺导致血清素耗竭的可逆和不可逆阶段。
Eur J Pharmacol. 1975 Aug;33(1):119-24. doi: 10.1016/0014-2999(75)90145-4.
5
Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms.氯苯丙胺噻吩类似物对中枢5-羟色胺能机制的影响。
J Med Chem. 1978 Sep;21(9):978-81. doi: 10.1021/jm00207a024.
6
Effect of p-chloroamphetamine on serotonin content of the rat pineal gland.对氯苯丙胺对大鼠松果体血清素含量的影响。
Res Commun Chem Pathol Pharmacol. 1977 Dec;18(4):769-72.
7
Long-term reduction of brain serotonin by p-chloroamphetamine: effects of inducers and inhibitors of drug metabolism.对氯苯丙胺对脑血清素的长期降低作用:药物代谢诱导剂和抑制剂的影响。
J Pharmacol Exp Ther. 1978 Aug;206(2):460-7.
8
Antagonism of the acute and long-term biochemical effects of 4-chloroamphetamine on the 5-HT neurones in the rat brain by inhibitors of the 5-hydroxytryptamine uptake.5-羟色胺摄取抑制剂对4-氯苯丙胺对大鼠脑内5-羟色胺神经元的急性和长期生化作用的拮抗作用
Acta Pharmacol Toxicol (Copenh). 1976;39(4):456-76. doi: 10.1111/j.1600-0773.1976.tb03197.x.
9
Comparison of the effects of lesion in the 'B9' cell body group and p-chloroamphetamine on tryptophan hydroxylase and 5-hydroxytryptamine in rat brain nuclei.“B9”细胞体群损伤与对氯苯丙胺对大鼠脑细胞核中色氨酸羟化酶和5-羟色胺影响的比较
Brain Res. 1975 Dec 12;100(1):140-4. doi: 10.1016/0006-8993(75)90249-8.
10
The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine.取代苯丙胺类药物,即3,4-亚甲基二氧甲基苯丙胺、甲基苯丙胺、对氯苯丙胺和芬氟拉明,通过一种被氟西汀和可卡因阻断的共同机制诱导5-羟色胺释放。
Eur J Pharmacol. 1992 May 14;215(2-3):153-60. doi: 10.1016/0014-2999(92)90023-w.

引用本文的文献

1
Effect of lesions of raphe nuclei on the activity of catecholaminergic and serotonergic neurones in various brain regions of the rat in vivo.中缝核损伤对大鼠活体不同脑区儿茶酚胺能和5-羟色胺能神经元活性的影响。
J Neural Transm. 1980;49(1-2):51-62. doi: 10.1007/BF01249189.
2
Modification of the noradrenergic cyclic AMP generating system in the rat limbic forebrain by amphetamine: role of its hydroxylated metabolites.苯丙胺对大鼠边缘前脑去甲肾上腺素能环磷酸腺苷生成系统的影响:其羟基化代谢产物的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):267-73. doi: 10.1007/BF00507113.