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Incorporation of H2 18O into 20alpha, 22R-di-OH cholesterol: evidence for an epoxide-diol pathway in the adrenocortical cholesterol side-chain cleavage mechanism.

作者信息

Kraaipoel R J, Degenhart H J, Leferink J G

出版信息

FEBS Lett. 1975 Oct 1;57(3):294-300. doi: 10.1016/0014-5793(75)80320-6.

DOI:10.1016/0014-5793(75)80320-6
PMID:1102334
Abstract
摘要

相似文献

1
Incorporation of H2 18O into 20alpha, 22R-di-OH cholesterol: evidence for an epoxide-diol pathway in the adrenocortical cholesterol side-chain cleavage mechanism.将H₂¹⁸O掺入20α, 22R-二羟基胆固醇:肾上腺皮质胆固醇侧链裂解机制中环氧二醇途径的证据。
FEBS Lett. 1975 Oct 1;57(3):294-300. doi: 10.1016/0014-5793(75)80320-6.
2
Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation.牛肾上腺皮质制剂中胆固醇向(22R)-22-羟胆固醇、(20R,22R)-20,22-二羟胆固醇和孕烯醇酮的酶促转化,以及(22R)-22-羟胆固醇向二醇和孕烯醇酮的质谱研究。氧掺入模式。
J Biol Chem. 1975 Dec 10;250(23):9028-37.
3
Exclusion of 20(22)-dehydrocholesterol as an intermediate in the biosynthesis of pregnenolone in bovine adrenocortical mitochondrial acetone-dried powder preparations.
Steroids. 1976 May;27(5):691-701. doi: 10.1016/s0039-128x(76)90224-5.
4
Inhibition of the conversion of cholesterol to pregnenolone in bovine adrenocortical preparations.在牛肾上腺皮质制剂中抑制胆固醇向孕烯醇酮的转化。
Steroids. 1976 Mar;27(3):361-82. doi: 10.1016/0039-128x(76)90057-x.
5
Mechanism of cholesterol side-chain cleavage. II. The enzymic hydroperoxide-glycol rearrangement of the epimeric 20-hydroperxycholesterols in 18O-enriched water.胆固醇侧链裂解的机制。II. 在富含18O的水中,差向异构的20-氢过氧胆固醇的酶促氢过氧化物-二醇重排反应
Biochim Biophys Acta. 1977 May 25;487(2):395-9. doi: 10.1016/0005-2760(77)90016-9.
6
Pregnenolone formation from cholesterol in bovine adrenal cortex mitochondria: proposal of a new mechanism.
FEBS Lett. 1975 Feb 1;50(2):204-9. doi: 10.1016/0014-5793(75)80489-3.
7
Biosynthesis of pregnenolone from cholesterol by mitochondrial enzymes of bovine adrenal cortex. The question of the participation of the 20(22)-olefins and 20, 22-epoxides of cholesterol.
Eur J Biochem. 1978 Nov 2;91(1):11-9. doi: 10.1111/j.1432-1033.1978.tb20931.x.
8
The stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3beta-hydroxypregn-5-en-20-one) catalysed by adrenal cytochrome P-450.肾上腺细胞色素P-450催化胆固醇和羟基胆固醇转化为孕烯醇酮(3β-羟基孕-5-烯-20-酮)的化学计量关系。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1441-5. doi: 10.1073/pnas.71.4.1441.
9
The role of cytochrome P-450 in the regulation of steroid biosynthesis.细胞色素P-450在甾体生物合成调控中的作用。
Adv Exp Med Biol. 1976;74:303-13. doi: 10.1007/978-1-4684-3270-1_23.
10
The recently proposed 20,22-epoxycholesterol as the intermediate in the conversion of cholesterol to pregnenolone by adrenal cortex mitochondria must be 5alpha,6alpha-epoxycholestan-3beta-ol.最近有人提出,肾上腺皮质线粒体将胆固醇转化为孕烯醇酮过程中的中间体20,22-环氧胆固醇必定是5α,6α-环氧胆甾烷-3β-醇。
Biochem Biophys Res Commun. 1978 Aug 29;83(4):1396-403. doi: 10.1016/0006-291x(78)91376-1.

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Bioassay-Guided Isolation of Guggulsterol I and Evaluation of Its Antioxidant Properties in Ethanol Extracts From Commiphora caudata Leaves.生物测定引导的古古甾醇I的分离及其对尾叶没药树叶乙醇提取物抗氧化性能的评估。
Cureus. 2024 Aug 29;16(8):e68166. doi: 10.7759/cureus.68166. eCollection 2024 Aug.
2
Cerebrotendinous xanthomatosis: a review of biochemical findings of the patient population in The Netherlands.脑腱黄瘤病:荷兰患者群体的生化检查结果综述
J Inherit Metab Dis. 1988;11(1):56-75. doi: 10.1007/BF01800057.
3
Cytochrome P450 in adrenocortical mitochondria.
肾上腺皮质线粒体中的细胞色素P450
Mol Cell Biochem. 1979 Mar 5;24(1):21-43. doi: 10.1007/BF00220191.