将H₂¹⁸O掺入20α, 22R-二羟基胆固醇：肾上腺皮质胆固醇侧链裂解机制中环氧二醇途径的证据。 - Suppr | 超能文献

Incorporation of H2 18O into 20alpha, 22R-di-OH cholesterol: evidence for an epoxide-diol pathway in the adrenocortical cholesterol side-chain cleavage mechanism.

作者信息

Kraaipoel R J, Degenhart H J, Leferink J G

出版信息

FEBS Lett. 1975 Oct 1;57(3):294-300. doi: 10.1016/0014-5793(75)80320-6.

DOI:10.1016/0014-5793(75)80320-6

Abstract

摘要

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Incorporation of H2 18O into 20alpha, 22R-di-OH cholesterol: evidence for an epoxide-diol pathway in the adrenocortical cholesterol side-chain cleavage mechanism.将H₂¹⁸O掺入20α, 22R-二羟基胆固醇：肾上腺皮质胆固醇侧链裂解机制中环氧二醇途径的证据。

FEBS Lett. 1975 Oct 1;57(3):294-300. doi: 10.1016/0014-5793(75)80320-6.

2

Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation.牛肾上腺皮质制剂中胆固醇向（22R）-22-羟胆固醇、（20R，22R）-20，22-二羟胆固醇和孕烯醇酮的酶促转化，以及（22R）-22-羟胆固醇向二醇和孕烯醇酮的质谱研究。氧掺入模式。

J Biol Chem. 1975 Dec 10;250(23):9028-37.

3

Exclusion of 20(22)-dehydrocholesterol as an intermediate in the biosynthesis of pregnenolone in bovine adrenocortical mitochondrial acetone-dried powder preparations.

Steroids. 1976 May;27(5):691-701. doi: 10.1016/s0039-128x(76)90224-5.

4

Inhibition of the conversion of cholesterol to pregnenolone in bovine adrenocortical preparations.在牛肾上腺皮质制剂中抑制胆固醇向孕烯醇酮的转化。

Steroids. 1976 Mar;27(3):361-82. doi: 10.1016/0039-128x(76)90057-x.

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Mechanism of cholesterol side-chain cleavage. II. The enzymic hydroperoxide-glycol rearrangement of the epimeric 20-hydroperxycholesterols in 18O-enriched water.胆固醇侧链裂解的机制。II. 在富含18O的水中，差向异构的20-氢过氧胆固醇的酶促氢过氧化物-二醇重排反应

Biochim Biophys Acta. 1977 May 25;487(2):395-9. doi: 10.1016/0005-2760(77)90016-9.

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Pregnenolone formation from cholesterol in bovine adrenal cortex mitochondria: proposal of a new mechanism.

FEBS Lett. 1975 Feb 1;50(2):204-9. doi: 10.1016/0014-5793(75)80489-3.

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Biosynthesis of pregnenolone from cholesterol by mitochondrial enzymes of bovine adrenal cortex. The question of the participation of the 20(22)-olefins and 20, 22-epoxides of cholesterol.

Eur J Biochem. 1978 Nov 2;91(1):11-9. doi: 10.1111/j.1432-1033.1978.tb20931.x.

8

The stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3beta-hydroxypregn-5-en-20-one) catalysed by adrenal cytochrome P-450.肾上腺细胞色素P-450催化胆固醇和羟基胆固醇转化为孕烯醇酮（3β-羟基孕-5-烯-20-酮）的化学计量关系。

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The role of cytochrome P-450 in the regulation of steroid biosynthesis.细胞色素P-450在甾体生物合成调控中的作用。

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The recently proposed 20,22-epoxycholesterol as the intermediate in the conversion of cholesterol to pregnenolone by adrenal cortex mitochondria must be 5alpha,6alpha-epoxycholestan-3beta-ol.最近有人提出，肾上腺皮质线粒体将胆固醇转化为孕烯醇酮过程中的中间体20,22-环氧胆固醇必定是5α,6α-环氧胆甾烷-3β-醇。

Biochem Biophys Res Commun. 1978 Aug 29;83(4):1396-403. doi: 10.1016/0006-291x(78)91376-1.

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