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环磷酰胺诱导的免疫耐受:恢复导致记忆状态。

Cyclophosphamide-induced immunological tolerance: recovery leads to a memory state.

作者信息

Botzenhardt U, Lemmel E M

出版信息

Folia Biol (Praha). 1975;21(4):280-2.

PMID:1102344
Abstract

Tolerance to SRBC has been induced in adult mice by the aid of cyclophosphamide, and the duration of the tolerant state has been tested by a second injection of antigen at different times thereafter. As evidenced by 19S and 7S PFC 4 days after challenge, tolerance in this model is of relatively short duration and leads spontaneously to a memory state.

摘要

借助环磷酰胺已在成年小鼠中诱导出对绵羊红细胞(SRBC)的耐受性,并且通过在之后不同时间再次注射抗原来测试耐受状态的持续时间。如攻击后4天19S和7S空斑形成细胞(PFC)所证明的,该模型中的耐受性持续时间相对较短,并会自发地转变为记忆状态。

相似文献

1
Cyclophosphamide-induced immunological tolerance: recovery leads to a memory state.环磷酰胺诱导的免疫耐受:恢复导致记忆状态。
Folia Biol (Praha). 1975;21(4):280-2.
2
Kinetics of the reactive cell clones after immunosuppression and induction of tolerance. II. Different recovery of 19 S and 7 S plaque-forming cells after induction of tolerance.免疫抑制和诱导耐受后反应性细胞克隆的动力学。II. 诱导耐受后19S和7S噬斑形成细胞的不同恢复情况。
Eur J Immunol. 1975 Oct;5(10):667-71. doi: 10.1002/eji.1830051003.
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[The effect of high doses of antigen on cyclophosphamide-induced immunosuppression].[高剂量抗原对环磷酰胺诱导的免疫抑制的影响]
Arzneimittelforschung. 1973 Jan;23(1):14-7.
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Mechanisms of antigen-induced blockade of immune response and cyclophosphamide-promoted tolerance to Salmonella typhi Vi antigen.抗原诱导的免疫反应阻断机制及环磷酰胺促进的对伤寒Vi抗原的耐受性
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Inability of the NZB-NZW F 1 thymus to transfer cyclophosphamide-induced tolerance to sheep erythrocytes.NZB-NZW F1 胸腺无法将环磷酰胺诱导的对绵羊红细胞的耐受性进行转移。
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[Study of different phases of immune tolerance induced in adult mice with the aid of cyclophosphamide].[借助环磷酰胺诱导成年小鼠免疫耐受不同阶段的研究]
Biull Eksp Biol Med. 1972 Jul;73(7):70-5.
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The thymus and recovery from cyclophosphamide-induced tolerance to sheep erythrocytes.胸腺与环磷酰胺诱导的对绵羊红细胞耐受性的恢复
J Exp Med. 1968 Jul 1;128(1):35-46. doi: 10.1084/jem.128.1.35.
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[Mechanisms of polyclonal tolerance induced by lipopolysaccharide and cyclophosphamide].[脂多糖和环磷酰胺诱导多克隆耐受的机制]
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[Drug-induced immune tolerance to sheep erythrocytes in mice of different lines].[不同品系小鼠对绵羊红细胞的药物诱导免疫耐受]
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