Vijayakumar R K, Muthukkaruppan V R
Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, India.
Immunology. 1990 Jun;70(2):181-5.
This paper describes the induction of immunosuppression by multiple injections of carrageenan-lambda (cgn) in BALB/c mice. While cgn alone induced non-specific suppression that persisted for up to 25 days, priming with sheep red blood cells (SRBC) of mice within 10 days of cgn treatment prolonged the suppressive state. Also, antigen (SRBC)-specific suppression was observed when these mice were given a secondary challenge 25-30 days afer priming. Thus multiple cgn treatment along with priming SRBC generated non-specific and specific suppressive states which were transferable by Thy-1+ Lyt-2+ splenocytes.
本文描述了在BALB/c小鼠中通过多次注射角叉菜胶-λ(cgn)诱导免疫抑制的情况。单独使用cgn可诱导持续长达25天的非特异性抑制,而在cgn治疗10天内用绵羊红细胞(SRBC)对小鼠进行致敏可延长抑制状态。此外,当这些小鼠在致敏后25 - 30天接受二次攻击时,观察到了抗原(SRBC)特异性抑制。因此,多次cgn治疗与致敏SRBC一起产生了可通过Thy-1 + Lyt-2 +脾细胞转移的非特异性和特异性抑制状态。