Akhyani N, Berti R, Brennan M B, Soldan S S, Eaton J M, McFarland H F, Jacobson S
Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
J Infect Dis. 2000 Nov;182(5):1321-5. doi: 10.1086/315893. Epub 2000 Oct 9.
Human herpesvirus (HHV)-6 has been associated with the pathogenesis of multiple sclerosis (MS) on the basis of serologic, molecular, and histopathologic studies. This study sought to determine the distribution of HHV-6 in different MS body fluids, including serum, saliva, urine, and peripheral blood lymphocytes. The study results extend the observation of an increased frequency of HHV-6 DNA in serum of patients with MS to the unique detection of viral sequences in urine of a subset of patients with MS. Moreover, the HHV-6 identified in these cell-free compartments was predominantly the HHV-6A variant, which has been reported to be neurotropic. These results support the hypothesis that HHV-6 may contribute to the MS disease process.
基于血清学、分子学和组织病理学研究，人类疱疹病毒6型（HHV-6）已被证实与多发性硬化症（MS）的发病机制有关。本研究旨在确定HHV-6在不同MS体液中的分布情况，这些体液包括血清、唾液、尿液和外周血淋巴细胞。研究结果不仅将MS患者血清中HHV-6 DNA频率增加的观察结果扩展到了部分MS患者尿液中病毒序列的独特检测，而且在这些无细胞区室中鉴定出的HHV-6主要是HHV-6A变体，据报道该变体具有嗜神经性。这些结果支持了HHV-6可能促成MS疾病进程的假说。
