Alcock K J, Passingham R E, Watkins K E, Vargha-Khadem F
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Brain Lang. 2000 Oct 15;75(1):17-33. doi: 10.1006/brln.2000.2322.
Half of the members of the KE family suffer from an inherited verbal dyspraxia. The affected members of the family have a lasting impairment in phonology and syntax. They were given various tests of oral praxis to investigate whether their deficit extends to nonverbal movements. Performance was compared to adult patients with acquired nonfluent dysphasia, those with comparable right-hemisphere lesions, and age-matched controls. Affected family members and patients with nonfluent dysphasia were impaired overall at performing oral movements, particularly combinations of movements. It is concluded that affected members of the KE family resemble patients with acquired dysphasia in having difficulties with oral praxis and that speech and language problems of affected family members arise from a lower level disorder.
KE家族中有一半成员患有遗传性言语失用症。该家族的患病成员在语音和句法方面存在持续性损伤。他们接受了各种口腔动作测试，以调查其缺陷是否扩展到非语言动作。将他们的表现与患有后天性非流利性失语症的成年患者、患有类似右半球损伤的患者以及年龄匹配的对照组进行了比较。患病家族成员和非流利性失语症患者在进行口腔动作，尤其是动作组合方面总体受损。得出的结论是，KE家族的患病成员在口腔动作方面存在困难，这与患有后天性失语症的患者相似，并且患病家族成员的言语和语言问题源于较低层次的障碍。
