Kastin A J, Pan W
VA Medical Center and Tulane University School of Medicine, 1601 Perdido St., 70112-1262, New Orleans, LA, USA.
Regul Pept. 2000 Aug 25;92(1-3):37-43. doi: 10.1016/s0167-0115(00)00147-6.
Regulation of the transport of leptin across the blood-brain barrier (BBB) may be crucial for its effects on food ingestion and obesity and may be responsible for 'leptin resistance'. This review summarizes current studies of leptin indicating a dynamic role of the BBB. It includes evidence for its susceptibility to change by physiological stimuli such as starvation, refeeding, and time of day. Although the short form of the leptin receptor is involved in leptin transport, it appears that other mechanisms of entry also exist. Regardless, the BBB is intimately involved with the regulation of the actions of leptin.
瘦素跨血脑屏障（BBB）转运的调节对于其对食物摄入和肥胖的影响可能至关重要，并且可能是“瘦素抵抗”的原因。本综述总结了当前关于瘦素的研究，表明血脑屏障具有动态作用。其中包括血脑屏障易受饥饿、再喂养和一天中的时间等生理刺激影响而发生变化的证据。尽管瘦素受体的短形式参与瘦素转运，但似乎还存在其他进入机制。无论如何，血脑屏障与瘦素作用的调节密切相关。
