普拉托霉素A和B I 产生菌的分类学以及普拉托霉素的生产、分离和生物学特性

Platomycins A and B I Taxonomy of the producing strain and production, isolation and biological properties of platomycins.

作者信息

Takasawa S, Kawamoto I, Takahashi I, Koakura M, Okachi R

出版信息

J Antibiot (Tokyo). 1975 Sep;28(9):656-61. doi: 10.7164/antibiotics.28.656.

DOI:10.7164/antibiotics.28.656

Abstract

Two new antibiotics, platomycins A and B, belonging to the phleomycin-bleomycin family, were isolated from the culture filtrate of Streptosporangium sp. MK-78. This strain has been identified as a new variety of Streptosporangium violaceochromogenes. Both platomycins A and B are active against a variety of Gram-positive and Gram-negative bacteria, and also inhibit solid Sarcoma 180 and Ehrlich ascites carcinoma.

摘要

从链孢囊菌属菌株MK-78的培养滤液中分离出两种新的抗生素，即博来霉素-平阳霉素家族的链黑菌素A和B。该菌株已被鉴定为紫产色链孢囊菌的一个新变种。链黑菌素A和B对多种革兰氏阳性菌和革兰氏阴性菌均有活性，还能抑制实体肉瘤180和艾氏腹水癌。