阿柔比星，一种新型蒽环类抗生素。I. 分类学、发酵、分离及理化性质。

Arugomycin, a new anthracycline antibiotic. I. Taxonomy, fermentation, isolation and physico-chemical properties.

作者信息

Kawai H, Hayakawa Y, Nakagawa M, Furihata K, Furihata K, Shimazu A, Seto H, Otake N

机构信息

Institute of Applied Microbiology, University of Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1987 Sep;40(9):1266-72. doi: 10.7164/antibiotics.40.1266.

DOI:10.7164/antibiotics.40.1266

PMID:3479412

Abstract

Arugomycin (AGM) is a new anthracycline antibiotic produced by strain No. 1098-AV2 which was identified as Streptomyces violaceochromogenes. AGM was isolated by solvent extraction, silicic acid chromatography and Sephadex LH-20 column chromatography. Acid treatment of AGM gave the chromophore, named arugorol, which was identified as 4'-epi-nogalarol, and sugar moieties. AGM inhibited the growth of Gram-positive bacteria and showed antitumor activity against sarcoma S-180 and Ehrlich ascites tumors.

摘要

阿柔比星（AGM）是由编号为1098-AV2的菌株产生的一种新型蒽环类抗生素，该菌株被鉴定为紫色产色链霉菌。AGM通过溶剂萃取、硅酸色谱和葡聚糖凝胶LH-20柱色谱进行分离。AGM经酸处理后得到发色团，命名为阿柔比星醇，其被鉴定为4'-表去甲加拉罗醇，以及糖部分。AGM抑制革兰氏阳性菌的生长，并对肉瘤S-180和艾氏腹水瘤显示出抗肿瘤活性。