Rabe T, van Staden J
Research Center for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, P./Bag X01, 3209, South, Scotsville, Africa.
J Ethnopharmacol. 2000 Nov;73(1-2):171-4. doi: 10.1016/s0378-8741(00)00293-2.
The bark of Warburgia salutaris is used in traditional medicine as an expectorant and smoked for coughs and colds, including a topical application for sores and inflammation. A previous screening of South African medicinal plants showed that this plant had promising antibacterial activity. Subsequently, this endangered tree species was selected for bioassay-guided fractionation in order to identify the active principles. Fractionation of the ethyl acetate extract of the stem bark by chromatographic techniques yielded a sesquiterpenoid which exhibited antimicrobial activity against Gram-positive bacteria. The compound, muzigadial, has previously been reported in two other Warburgia species, this being the first time it has been reported from W. salutaris. Muzigadial had minimum inhibitory concentration values ranging from 12.5 to 100 microg ml(-1).
南非香叶树的树皮在传统医学中用作祛痰剂，用于治疗咳嗽和感冒，包括用于治疗疮和炎症的局部应用。先前对南非药用植物的筛选表明，这种植物具有良好的抗菌活性。随后，选择这种濒危树种进行生物测定导向的分级分离，以鉴定其活性成分。通过色谱技术对茎皮的乙酸乙酯提取物进行分级分离，得到一种倍半萜类化合物，该化合物对革兰氏阳性菌具有抗菌活性。该化合物，穆齐加迪尔，先前已在另外两种南非香叶树中报道过，这是首次从南非香叶树中报道。穆齐加迪尔的最低抑菌浓度值范围为12.5至100微克/毫升。
