Chung Ill-Min, Moon Hyung-In
Department of Applied Life science, Kon Kuk University, Seoul, 143-701, South Korea.
J Enzyme Inhib Med Chem. 2009 Feb;24(1):131-5. doi: 10.1080/14756360801936274.
The whole plant of genus Carpesium is used in traditional medicine as an anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. Previous experiments on Carpesium rosulatum suggested that the antiplasmodial effect was due to the existence of ineupatorolide A. In present paper, screening of Carpesium species from South Korea showed that this plant refers to which species had promising antiplasmodial activity. Subsequently, this species was selected for bioassay-guided fractionation in order to identify the active principles. Fractionation of the ethyl acetate extract of the whole plants by chromatographic techniques yielded four characterised sesquiterpenoid lactones which exhibited antiplasmodial activity against Plasmodium falciparum. This being the first time that this has been reported from Carpesium cernum. The antiplasmodial activity of the isolated compounds was determined against the Plasmodium falciparum.
天名精属植物全草在传统医学中用作退烧药、镇痛药和驱虫药，包括用于治疗疮疡和炎症的外用制剂。先前对莲座叶天名精的实验表明，其抗疟作用归因于存在紫茎泽兰内酯A。在本文中，对韩国天名精属植物的筛选表明，该植物属于具有良好抗疟活性的物种。随后，选择该物种进行生物活性导向的分离，以鉴定其活性成分。通过色谱技术对全草的乙酸乙酯提取物进行分离，得到了四种具有特征的倍半萜内酯，它们对恶性疟原虫具有抗疟活性。这是首次从烟管头草中报道此类情况。测定了分离出的化合物对恶性疟原虫的抗疟活性。
