La Rosa F, Stracci F, Petrinelli A M, Casucci P, Mastrandrea V
Department of Hygiene, Perugia University, Perugia, Italy.
Eur Urol. 2000 Oct;38(4):388-92. doi: 10.1159/000020313.
Incidence, mortality and long-term survival from prostate cancer were examined in the Umbria region of Italy, for the period 1978-1994. Incidence rates were derived from an ad hoc survey carried out over the period 1978-1982 and from 1994 cancer registry records. The mortality over the period derived from data of the official publications and the survival rates, at 15 years, were calculated starting from the ad hoc survey incident cases.
In the Umbria region, over the period 1978-1994, crude incidence rates from prostate cancer increased from 31.2 to 81. 9 per 100,000 and mortality rates from 22.7 to 31.9 per 100,000. The rates were from 30.5 to 61.2 for age-adjusted incidence while standardized mortality remained constant (from 22.6 to 22.7 per 100, 000). Survival in Umbria, compared with rates from other European Cancer Registries, is low both at 5- and 10-year follow-up.
The great incidence increase observed over the study period could depend on a lesser completeness achieved by the 1978-1982 ad hoc survey with respect to the 1994 cancer registry data and/or from the screening campaign carried out in a large part of the region in 1994. Different elements support these hypotheses. However the above hypotheses can be verified over the next years when further incidence and survival data from the cancer registry will be available.
对意大利翁布里亚地区1978 - 1994年期间前列腺癌的发病率、死亡率及长期生存率进行了研究。发病率数据来源于1978 - 1982年期间开展的专项调查以及1994年癌症登记记录。该时期的死亡率来自官方出版物数据，15年生存率则从专项调查的发病病例开始计算。
在翁布里亚地区，1978 - 1994年期间，前列腺癌的粗发病率从每10万人31.2例增至81.9例，死亡率从每10万人22.7例增至31.9例。年龄调整后的发病率为30.5至61.2例，而标准化死亡率保持不变（每10万人从22.6例至22.7例）。与其他欧洲癌症登记处的比率相比，翁布里亚地区在5年和10年随访时的生存率较低。
在研究期间观察到的发病率大幅上升可能取决于1978 - 1982年专项调查相对于1994年癌症登记数据的完整性较低，和/或该地区大部分地区在1994年开展的筛查活动。不同因素支持这些假设。然而，当未来可获得癌症登记处更多的发病率和生存数据时，上述假设将在接下来的几年得到验证。
