Wachsmuth I K, Stamm W E, McGowan J E
J Infect Dis. 1975 Nov;132(5):601-3. doi: 10.1093/infdis/132.5.601.
The pathogenesis of gastrointestinal infections caused by Escherichia coli has been attributed to the ability of some strains to produce exotoxins (enterotoxins) or to invade the intestinal mucosa directly. To investigate the possible role of invasiveness and of production of toxin in the pathogenesis of nonenteric E. coli infections, we studied E. coli isolated from 152 patients with urinary tract infections, bacteremia, or both. None of the isolates from urine or blood exhibited invasiveness in the guinea pig eye or produced toxin in tissue culture or in infant mice; only one patient was a gastrointestinal carrier of toxin-producing E. coli. We concluded that, in the population of this study, production of toxin and invasiveness were not important in the pathogenesis of most urinary tract infections or bacteremia caused by E. coli, and that gastrointestinal colonization with such organisms was uncommon.
大肠杆菌引起的胃肠道感染的发病机制归因于某些菌株产生外毒素（肠毒素）或直接侵入肠黏膜的能力。为了研究侵袭性和毒素产生在非肠道大肠杆菌感染发病机制中的可能作用，我们对从152例患有尿路感染、菌血症或两者皆有的患者中分离出的大肠杆菌进行了研究。从尿液或血液中分离出的菌株在豚鼠眼中均未表现出侵袭性，在组织培养或幼鼠中也未产生毒素；只有一名患者是产毒素大肠杆菌的胃肠道携带者。我们得出结论，在本研究人群中，毒素产生和侵袭性在大多数由大肠杆菌引起的尿路感染或菌血症的发病机制中并不重要，并且此类生物体在胃肠道的定植并不常见。
