异羟肟酸铁载体（气杆菌素）与从菌血症患者分离出的大肠杆菌的关联。
Association of hydroxamate siderophore (aerobactin) with Escherichia coli isolated from patients with bacteremia.
作者信息
Montgomerie J Z, Bindereif A, Neilands J B, Kalmanson G M, Guze L B
出版信息
Infect Immun. 1984 Dec;46(3):835-8. doi: 10.1128/iai.46.3.835-838.1984.
Abstract
Clinical isolates of Escherichia coli were examined for the presence of hydroxamate siderophore (aerobactin). The incidence of aerobactin-positive strains of E. coli from the blood was greater than the incidence of these strains isolated from other sites. The presence of aerobactin and the virulence of strains of E. coli in urinary tract infection were also examined in mice. The presence of aerobactin in the strains of E. coli correlated with virulence as measured by proportion of deaths but not with renal infection. These results suggest that the presence of aerobactin may be a significant factor in the invasion of the blood stream.
摘要
对大肠杆菌的临床分离株进行了异羟肟酸铁载体（气杆菌素）检测。血液中分离出的气杆菌素阳性大肠杆菌菌株的发生率高于从其他部位分离出的这些菌株的发生率。还在小鼠中检测了气杆菌素的存在与大肠杆菌菌株在尿路感染中的毒力。大肠杆菌菌株中气杆菌素的存在与通过死亡比例衡量的毒力相关，但与肾脏感染无关。这些结果表明，气杆菌素的存在可能是血液感染的一个重要因素。
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