Keevil B, Rowlands D, Burton I, Webb A K
Department of Clinical Biochemistry, South Manchester University Hospital (NHS) Trust, UK.
Ann Clin Biochem. 2000 Sep;37 ( Pt 5):662-5. doi: 10.1258/0004563001899708.
We investigated the use of soluble transferrin receptor (sTfR), together with more traditional measurements such as iron, transferrin and ferritin, to assess iron status in 70 adult cystic fibrosis patients. sTfR concentration was measured using particle-enhanced immunonephelometry. We found that 69% of subjects as determined by transferrin saturation had iron deficiency, but only 29% as determined by sTfR and 11% as determined by ferritin. We found a significant correlation between C-reactive protein (CRP) and both ferritin (r = 0.38, P = 0.0001) and transferrin saturation (r = -0.54, P < 0.0001). In addition, because the CRP concentration was elevated in 64% of subjects, we feel that the transferrin saturation was overestimating, and the ferritin underestimating, iron deficiency in these patients. The sTfR concentration, on the other hand, is unaffected by the acute-phase response and was therefore thought to be the most useful test for detecting iron deficiency in this group of patients.
我们研究了可溶性转铁蛋白受体（sTfR）与铁、转铁蛋白和铁蛋白等更传统检测指标一起用于评估70例成年囊性纤维化患者铁状态的情况。采用颗粒增强免疫比浊法测定sTfR浓度。我们发现，根据转铁蛋白饱和度判定，69%的受试者存在缺铁，但根据sTfR判定只有29%，根据铁蛋白判定为11%。我们发现C反应蛋白（CRP）与铁蛋白（r = 0.38，P = 0.0001）和转铁蛋白饱和度（r = -0.54，P < 0.0001）均存在显著相关性。此外，由于64%的受试者CRP浓度升高，我们认为在这些患者中转铁蛋白饱和度高估了缺铁情况，而铁蛋白低估了缺铁情况。另一方面，sTfR浓度不受急性期反应的影响，因此被认为是检测该组患者缺铁最有用的检测方法。
