Frankel B, Longo S L, Canute G W
Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
J Neurooncol. 2000 May;48(1):21-6. doi: 10.1023/a:1006473800589.
Gliomas of all grades have been shown to express FasL, an apoptosis-inducing protein. Because of the ability of FasL to be cleaved from cell surfaces by metalloproteinases, soluble FasL can be released by FasL bearing cells into surrounding tissues. In the present study, we demonstrate the presence of sFasL in the cyst fluids of astrocytomas. Additionally, a human T-cell line, Jurkat, exposed to astrocytoma cyst fluid resulted in significantly increased cytotoxicity as compared to controls, an effect blocked by FasL neutralizing antibodies. This suggests that sFasL, may be utilized as a means of escaping immune surveillance by these tumors.
所有级别的胶质瘤均已被证明可表达FasL，一种诱导凋亡的蛋白。由于FasL能够被金属蛋白酶从细胞表面切割下来，可溶性FasL可由表达FasL的细胞释放到周围组织中。在本研究中，我们证实在星形细胞瘤的囊液中存在可溶性FasL。此外，与对照组相比，暴露于星形细胞瘤囊液的人T细胞系Jurkat的细胞毒性显著增加，而FasL中和抗体可阻断这一效应。这表明可溶性FasL可能被这些肿瘤用作逃避免疫监视的一种方式。
