Kokubo M, Shibamoto Y, Takahashi J A, Sasai K, Oya N, Hashimoto N, Hiraoka M
Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto, Japan.
J Neurooncol. 2000 May;48(1):51-5. doi: 10.1023/a:1006430102406.
Results of radiation therapy for 20 patients with recurrent meningioma were analyzed. The patients included 8 men and 12 women, with a median age of 55 years. All of the patients had undergone at least one operation prior to the reoperation preceding radiotherapy. Ten patients had benign meningiomas, while 4 and 6 patients had atypical and malignant meningiomas, respectively, at the time of radiotherapy. The median radiation dose was 59.4 Gy (range: 50-61.2 Gy). The local control rate at 5 years was 36% for all 20 patients (41% for benign meningiomas and 30% for atypical or malignant meningiomas). The 5-year survival rate was 47%. Excluding 2 patients whose follow-up period was shorter than the preradiotherapy interval from the previous operation, the postradiation recurrence-free period was longer than the preradiotherapy interval in 50% (9/18) of the patients. No serious complications of radiotherapy were observed. Radiotherapy seemed to be effective in controlling the tumor or delaying recurrence in at least half of the patients. However, higher doses of radiation, using sophisticated radiation techniques, may be necessary to obtain higher control rates.
分析了20例复发性脑膜瘤患者的放射治疗结果。患者包括8名男性和12名女性，中位年龄为55岁。所有患者在放疗前的再次手术前至少接受过一次手术。放疗时，10例患者为良性脑膜瘤，4例和6例患者分别为非典型和恶性脑膜瘤。中位放射剂量为59.4 Gy（范围：50 - 61.2 Gy）。20例患者的5年局部控制率为36%（良性脑膜瘤为41%，非典型或恶性脑膜瘤为30%）。5年生存率为47%。排除2例随访期短于上次手术放疗前间隔的患者后，50%（9/18）的患者放疗后的无复发生存期长于放疗前间隔。未观察到放疗的严重并发症。放疗似乎对至少一半的患者有效控制肿瘤或延迟复发。然而，可能需要使用先进的放射技术给予更高剂量的辐射以获得更高的控制率。
