Graff R J, Valeriote F, Medoff G
J Natl Cancer Inst. 1975 Oct;55(4):1015-6. doi: 10.1093/jnci/55.4.1015.
Sublines of AKR mice differed significantly in their histoincompatibility to AKR/J mice, as indicated by their ability to reject AKR/J skin grafts and an AKR transplantable leukemia. Further, all sublines tested demonstrated some degree of heterogeneity, because isografts were rejected in 5-97% of the mice, depending on the subline. The presence of excessive heterogeneity among and within sublines poses a serious problem for experimental oncologists using these sublines in their tumor models.
AKR小鼠的亚系对AKR/J小鼠的组织相容性存在显著差异，这可通过它们排斥AKR/J皮肤移植和一种AKR可移植白血病的能力来表明。此外，所有测试的亚系都表现出一定程度的异质性，因为同基因移植在5%至97%的小鼠中被排斥，具体取决于亚系。亚系之间以及亚系内部存在的过度异质性给在肿瘤模型中使用这些亚系的实验肿瘤学家带来了严重问题。
