Rab GDP解离抑制剂α在调节海马神经传递可塑性中的作用。
Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.
作者信息
Ishizaki H, Miyoshi J, Kamiya H, Togawa A, Tanaka M, Sasaki T, Endo K, Mizoguchi A, Ozawa S, Takai Y
机构信息
Takai Biotimer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, c/o JCR Pharmaceuticals, Kobe 651-2241, Japan.
出版信息
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11587-92. doi: 10.1073/pnas.97.21.11587.
Abstract
Rab GDP dissociation inhibitor alpha (Rab GDIalpha) is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIalpha cause human X-linked mental retardation associated with epileptic seizures. In Rab GDIalpha-deficient mice, synaptic potentials in the CA1 region of the hippocampus displayed larger enhancement during repetitive stimulation, which was apparently opposite to the phenotype of Rab3A-deficient mice. Furthermore, the Rab GDIalpha-deficient mice showed hypersensitivity to bicuculline, an inducer of epileptic seizures. These results suggest that Rab GDIalpha plays a specialized role in Rab3A recycling to suppress hyperexcitability via modulation of presynaptic forms of plasticity.
摘要
Rab GDP解离抑制剂α（Rab GDIα）是参与神经传递的Rab小G蛋白的调节剂，Rab GDIα的突变会导致与癫痫发作相关的人类X连锁智力迟钝。在缺乏Rab GDIα的小鼠中，海马体CA1区的突触电位在重复刺激期间表现出更大的增强，这显然与缺乏Rab3A的小鼠的表型相反。此外，缺乏Rab GDIα的小鼠对癫痫发作诱导剂荷包牡丹碱表现出超敏反应。这些结果表明，Rab GDIα在Rab3A再循环中发挥特殊作用，通过调节突触前可塑性形式来抑制过度兴奋。
相似文献
1
Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.Rab GDP解离抑制剂α在调节海马神经传递可塑性中的作用。
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11587-92. doi: 10.1073/pnas.97.21.11587.
2
Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.Rab3 GTP酶激活蛋白通过使Rab3失活来调节突触传递和可塑性。
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10029-34. doi: 10.1073/pnas.0600304103. Epub 2006 Jun 16.
3
Use of Hsp90 inhibitors to disrupt GDI-dependent Rab recycling.使用热休克蛋白90（Hsp90）抑制剂破坏GDI依赖的Rab循环。
Methods Enzymol. 2005;403:339-47. doi: 10.1016/S0076-6879(05)03029-6.
4
Altered synaptic dynamics and hippocampal excitability but normal long-term plasticity in mice lacking hyperpolarizing GABA A receptor-mediated inhibition in CA1 pyramidal neurons.在CA1锥体神经元中缺乏超极化GABAA受体介导的抑制作用的小鼠，其突触动力学和海马兴奋性发生改变，但长期可塑性正常。
J Neurophysiol. 2008 Jun;99(6):3075-89. doi: 10.1152/jn.00606.2007. Epub 2008 Apr 24.
5
Hyperexcitability induced by GABA withdrawal facilitates hippocampal long-term potentiation.γ-氨基丁酸（GABA）撤离诱导的兴奋性增强促进海马体长期增强效应。
Neuroscience. 2004;126(1):163-71. doi: 10.1016/j.neuroscience.2004.03.029.
6
Actions and expression of RAB-GDP dissociation inhibitor in dispersed chief cells from guinea pig stomach.RAB-GDP解离抑制剂在豚鼠胃分散主细胞中的作用及表达
Biochem Biophys Res Commun. 1996 Aug 5;225(1):232-7. doi: 10.1006/bbrc.1996.1159.
7
Facilitated CA1 hippocampal synaptic plasticity in dystrophin-deficient mice: role for GABAA receptors?肌营养不良蛋白缺乏小鼠海马CA1区突触可塑性的易化：γ-氨基丁酸A型受体的作用？
Hippocampus. 2002;12(6):713-7. doi: 10.1002/hipo.10068.
8
N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus.CA1区中N-甲基-D-天冬氨酸受体依赖性长时程增强作用影响整个海马体中谷氨酸受体亚基及相关蛋白的突触表达。
Neuroscience. 2006 Sep 1;141(3):1399-413. doi: 10.1016/j.neuroscience.2006.04.070. Epub 2006 Jun 12.
9
Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha.缺乏Rho GDIα的小鼠中肾脏和生殖器官的进行性损伤。
Oncogene. 1999 Sep 23;18(39):5373-80. doi: 10.1038/sj.onc.1202921.
10
Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.在雷特综合征的Mecp2基因敲除小鼠模型中，海马体突触可塑性受损。
Neurobiol Dis. 2006 Jan;21(1):217-27. doi: 10.1016/j.nbd.2005.07.005. Epub 2005 Aug 8.
引用本文的文献
1
Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer.GDP 解离抑制因子 1 基因的过表达与结直肠癌的侵袭性和不良预后相关。
Bioengineered. 2021 Dec;12(1):5595-5606. doi: 10.1080/21655979.2021.1967031.
2
Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.转录组分析为不同年龄的田螺中枢神经系统提供了基因组注释和表达谱。
BMC Genomics. 2021 Sep 3;22(1):637. doi: 10.1186/s12864-021-07946-y.
3
Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain.野生型小鼠大脑中艾杜糖醛酸-2-硫酸酯酶蛋白质组的鉴定。
Heliyon. 2019 May 10;5(5):e01667. doi: 10.1016/j.heliyon.2019.e01667. eCollection 2019 May.
4
MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.视网膜色素上皮中的MERTK信号传导调节来自RAB GTP酶效应器的GDI/CHM家族的GDP解离抑制剂α的酪氨酸磷酸化。
Exp Eye Res. 2015 Nov;140:28-40. doi: 10.1016/j.exer.2015.08.006. Epub 2015 Aug 15.
5
Binocular pattern deprivation interferes with the expression of proteins involved in primary visual cortex maturation in the cat.双眼模式剥夺会干扰猫初级视觉皮层成熟过程中所涉及蛋白质的表达。
Mol Brain. 2015 Aug 14;8:48. doi: 10.1186/s13041-015-0137-7.
6
Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats.大鼠经角膜电刺激相关视网膜蛋白的蛋白质组学研究
J Ophthalmol. 2015;2015:492050. doi: 10.1155/2015/492050. Epub 2015 Mar 4.
7
Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling.散发性克雅氏病亚型特异性脑蛋白质组改变：对 Rab3a 回收的影响。
Proteomics. 2012 Dec;12(23-24):3610-20. doi: 10.1002/pmic.201200201. Epub 2012 Dec 12.
8
Altered short-term plasticity in the prefrontal cortex after early life seizures.早期生活痫性发作后前额叶皮层短期可塑性改变。
Neurobiol Dis. 2013 Feb;50:120-6. doi: 10.1016/j.nbd.2012.10.007. Epub 2012 Oct 12.
9
Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.Gdi1基因缺陷小鼠的认知障碍与突触小泡池改变和短期突触可塑性有关，并且可以通过适当的学习训练得到纠正。
Hum Mol Genet. 2009 Jan 1;18(1):105-17. doi: 10.1093/hmg/ddn321. Epub 2008 Oct 1.
10
Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves.神经瘤的蛋白质组学分析揭示了过度兴奋神经中蛋白质组成和局部蛋白质合成的改变。
Mol Pain. 2008 Aug 12;4:33. doi: 10.1186/1744-8069-4-33.
本文引用的文献
1
X-linked mental retardation syndrome with short stature, small hands and feet, seizures, cleft palate, and glaucoma is linked to Xq28.伴有身材矮小、手足短小、癫痫发作、腭裂和青光眼的X连锁智力发育迟缓综合征与Xq28相关。
Am J Med Genet. 1999 Jul 30;85(3):236-42. doi: 10.1002/(sici)1096-8628(19990730)85:3<236::aid-ajmg10>3.0.co;2-9.
2
Dual mechanism for presynaptic modulation by axonal metabotropic glutamate receptor at the mouse mossy fibre-CA3 synapse.轴突代谢型谷氨酸受体对小鼠苔藓纤维 - CA3 突触进行突触前调制的双重机制。
J Physiol. 1999 Jul 15;518 ( Pt 2)(Pt 2):497-506. doi: 10.1111/j.1469-7793.1999.0497p.x.
3
Electrophysiology of synaptic vesicle cycling.突触囊泡循环的电生理学
Annu Rev Physiol. 1999;61:725-52. doi: 10.1146/annurev.physiol.61.1.725.
4
Mutations in GDI1 are responsible for X-linked non-specific mental retardation.GDI1基因的突变是X连锁非特异性智力障碍的病因。
Nat Genet. 1998 Jun;19(2):134-9. doi: 10.1038/487.
5
Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process.Tomosyn：一种与 syntaxin-1 结合的蛋白，在神经递质释放过程中形成一种新型复合物。
Neuron. 1998 May;20(5):905-15. doi: 10.1016/s0896-6273(00)80472-9.
6
K-ras is essential for the development of the mouse embryo.K-ras 对小鼠胚胎发育至关重要。
Oncogene. 1997 Sep 4;15(10):1151-9. doi: 10.1038/sj.onc.1201284.
7
The diversity of Rab proteins in vesicle transport.Rab蛋白在囊泡运输中的多样性。
Curr Opin Cell Biol. 1997 Aug;9(4):496-504. doi: 10.1016/s0955-0674(97)80025-7.
8
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus.Rab3A对海马体苔藓纤维长时程增强至关重要。
Nature. 1997 Aug 7;388(6642):590-3. doi: 10.1038/41574.
9
The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion.小GTP结合蛋白Rab3A调节突触小泡融合的后期步骤。
Nature. 1997 Jun 19;387(6635):810-4. doi: 10.1038/42954.
10
Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosis.Rab3A：一种参与钙离子依赖型胞吐作用的小GTP结合蛋白。
Genes Cells. 1996 Jul;1(7):615-32. doi: 10.1046/j.1365-2443.1996.00257.x.
Zotero 插件