Fürstner A
Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1, 45470 Mülheim/Ruhr (Germany).
Angew Chem Int Ed Engl. 2000 Sep 1;39(17):3012-3043.
The advent of well-defined catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups has revolutionized the field. The past decade has seen the rapid embrace of these reagents as tools for advanced organic and polymer chemistry and the success of this development is witnessed by a plethora of elegant applications to the synthesis of natural and nonnatural products. This review article provides an overview of these developments and intends to familiarize the reader with some very recent advances which hold the promise to expand the scope of the reaction even further. Moreover, the positive impact of metathesis on the fundamental logic of retrosynthetic planning is demonstrated by means of typical examples. Finally, it will be shown that metathesis is by no means restricted to alkenes as substrates, and some comments on metathesis reactions following unconventional mechanistic pathways will also be presented.
具有高活性、耐久性且对极性官能团具有出色耐受性的明确烯烃复分解催化剂的出现，彻底改变了该领域。在过去十年中，这些试剂迅速成为先进有机化学和高分子化学的工具，大量用于天然和非天然产物合成的精妙应用见证了这一发展的成功。这篇综述文章概述了这些进展，并旨在让读者熟悉一些最新进展，这些进展有望进一步扩大反应的范围。此外，通过典型例子展示了复分解对逆合成规划基本逻辑的积极影响。最后，将表明复分解绝不仅限于以烯烃为底物，还将对遵循非常规机理途径的复分解反应进行一些评论。
