用一种新的泼尼松龙苯丁酸氮芥酯（Leo 1031，NSC - 134087）治疗慢性淋巴细胞白血病和淋巴肉瘤。

Treatment of chronic lymphocytic leukemia and lymphosarcoma with a new chlorambucil ester of prednisolone (Leo 1031) (NSC-134087).

作者信息

Aungst C W, Mittelman A, Murphy G P

出版信息

J Surg Oncol. 1975;7(6):457-60. doi: 10.1002/jso.2930070604.

DOI:10.1002/jso.2930070604

Abstract

A new chlorambucil ester of prednisolone (LEO 1031) has been evaluated in patients with advanced lymphocytic lymphosarcoma and chronic lymphocytic leukemia. All 11 patients had been previously treated with radiotherapy and/or combination chemotherapy. Three complete remissions and one partial remission were seen in 4/7 lymphocytic lymphosarcoma patients treated with LEO 1031. In the chronic lymphocytic leukemia group, 3/4 have had benefit. This new drug is considered worthy of further trial.

摘要

一种新的泼尼松龙苯丁酸氮芥酯（LEO 1031）已在晚期淋巴细胞性淋巴肉瘤和慢性淋巴细胞白血病患者中进行了评估。所有11例患者此前均接受过放疗和/或联合化疗。在接受LEO 1031治疗的7例淋巴细胞性淋巴肉瘤患者中，有4例出现3例完全缓解和1例部分缓解。在慢性淋巴细胞白血病组中，4例中有3例受益。这种新药被认为值得进一步试验。

相似文献

1

Treatment of chronic lymphocytic leukemia and lymphosarcoma with a new chlorambucil ester of prednisolone (Leo 1031) (NSC-134087).用一种新的泼尼松龙苯丁酸氮芥酯（Leo 1031，NSC - 134087）治疗慢性淋巴细胞白血病和淋巴肉瘤。

J Surg Oncol. 1975;7(6):457-60. doi: 10.1002/jso.2930070604.

2

Prednimustine (NSC-134087, Leo 1031) treatment of lymphocytic and lymphocytic-histiocytic lymphomas.

Cancer. 1978 Jan;41(1):112-6. doi: 10.1002/1097-0142(197801)41:1<112::aid-cncr2820410117>3.0.co;2-c.

3

A phase II clinical trial of prednimustine. Clinical screening cooperative group of E.O.R.T.C.

Biomedicine. 1977 Jun;27(4):158-61.

4

Clinical trial of prednimustine, Leo-1031 (NSC-134087), in patients with non-Hodgkin lymphomata and chronic lymphocytic leukaemia previously treated with steroids and alkylating agents.

Acta Med Scand. 1980;207(3):215-20. doi: 10.1111/j.0954-6820.1980.tb09708.x.

5

Therapeutic effect of Leo 1031, an alkylating corticosteroid ester, in lymphoproliferative disorders. I. chronic lymphocytic leukaemia.

Acta Med Scand. 1975 Apr;197(4):317-22. doi: 10.1111/j.0954-6820.1975.tb04925.x.

6

Treatment of chronic lymphocytic leukaemia and well-differentiated lymphocytic lymphoma with continuous low- or intermittent high-dose prednimustine versus chlorambucil/prednisolone.连续低剂量或间歇性高剂量泼尼松氮芥与苯丁酸氮芥/泼尼松治疗慢性淋巴细胞白血病和高分化淋巴细胞淋巴瘤的对比研究

Eur J Cancer Clin Oncol. 1982 Nov;18(11):1117-23. doi: 10.1016/0277-5379(82)90092-x.

7

Therapeutic effect of Leo 1031, an alkylating corticosteroid ester; in lymphoproliferative disorders. II. Lymphocytic lymphoma.烷化皮质类固醇酯Leo 1031对淋巴增生性疾病的治疗作用。II. 淋巴细胞性淋巴瘤

Acta Med Scand. 1975 Apr;197(4):323-7. doi: 10.1111/j.0954-6820.1975.tb04926.x.

8

Complete remission in chronic lymphocytic leukemia and leukolymphosarcoma.慢性淋巴细胞白血病和淋巴肉瘤的完全缓解

Cancer. 1967 Feb;20(2):243-53. doi: 10.1002/1097-0142(1967)20:2<243::aid-cncr2820200210>3.0.co;2-x.

9

[Effect of Prednimustine (Leo 1031) in chronic lymphatic leukemia].

Osterr Z Onkol. 1977;3(5-6):155-9.

10

Phase II trial of Prednimustine. Leo-1031 (NSC-134087) in acute non-lymphocytic leukemia.

Scand J Haematol. 1979 Nov;23(5):388-92. doi: 10.1111/j.1600-0609.1979.tb02738.x.

引用本文的文献

1

Phase II trial of prednimustine (NSC-134087) in the treatment of small-cell anaplastic carcinoma of the lung.泼尼莫司汀（NSC-134087）治疗肺小细胞间变性癌的II期试验。

Cancer Chemother Pharmacol. 1980;4(4):259-61. doi: 10.1007/BF00255270.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。