用一种新的泼尼松龙苯丁酸氮芥酯（Leo 1031，NSC - 134087）治疗慢性淋巴细胞白血病和淋巴肉瘤。
Treatment of chronic lymphocytic leukemia and lymphosarcoma with a new chlorambucil ester of prednisolone (Leo 1031) (NSC-134087).
作者信息
Aungst C W, Mittelman A, Murphy G P
出版信息
J Surg Oncol. 1975;7(6):457-60. doi: 10.1002/jso.2930070604.
A new chlorambucil ester of prednisolone (LEO 1031) has been evaluated in patients with advanced lymphocytic lymphosarcoma and chronic lymphocytic leukemia. All 11 patients had been previously treated with radiotherapy and/or combination chemotherapy. Three complete remissions and one partial remission were seen in 4/7 lymphocytic lymphosarcoma patients treated with LEO 1031. In the chronic lymphocytic leukemia group, 3/4 have had benefit. This new drug is considered worthy of further trial.
一种新的泼尼松龙苯丁酸氮芥酯（LEO 1031）已在晚期淋巴细胞性淋巴肉瘤和慢性淋巴细胞白血病患者中进行了评估。所有11例患者此前均接受过放疗和/或联合化疗。在接受LEO 1031治疗的7例淋巴细胞性淋巴肉瘤患者中，有4例出现3例完全缓解和1例部分缓解。在慢性淋巴细胞白血病组中，4例中有3例受益。这种新药被认为值得进一步试验。
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