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对于“不愈合”的下肢静脉溃疡,手术切除溃疡及脂膜炎性硬化,随后进行中厚皮片移植(削痂疗法)可取得良好的长期效果。

Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers.

作者信息

Schmeller W, Gaber Y

机构信息

Rosenparkklinik, Darmstadt, Germany.

出版信息

Acta Derm Venereol. 2000 Jul-Aug;80(4):267-71. doi: 10.1080/000155500750012144.

Abstract

The purpose of this study was to evaluate the long-term effects of shave therapy in non-healing venous leg ulcers. Forty-one patients with 75 recalcitrant leg ulcers caused by primary deep vein incompetence or post-thrombotic syndrome were operated by shave therapy (removal of ulcer and surrounding lipodermatosclerosis with a Schink skin-grafting knife and covering of the wounds with meshed split-thickness skin grafts). After an average follow-up period of 2 years and 5 months all patients were evaluated for long-term results. The healing rate of ulcers classified as non-healing was 67% (50 of 75 ulcers). The healing rate was 76% for ulcers associated with primary deep vein incompetence and 58% for ulcers associated with post-thrombotic syndrome (p = 0.08). Even in cases with recurrence (33%) these ulcers were strikingly reduced by 80-90% of their original size. Hypaesthesia was noticed in 38% of the transplanted areas. In "non-healing" venous leg ulcers due to deep venous insufficiency shave therapy yields favourable long-term results. Because it is only a symptomatic treatment which does not reduce the pathological refluxes, continuous compression of the lower leg is important.

摘要

本研究的目的是评估削痂疗法对难愈性下肢静脉溃疡的长期疗效。41例因原发性深静脉瓣膜功能不全或血栓形成后综合征导致75处顽固性下肢溃疡的患者接受了削痂疗法(用Schink植皮刀切除溃疡及周围的脂肪硬化皮肤,并用网状中厚皮片覆盖创面)。在平均随访2年零5个月后,对所有患者的长期疗效进行评估。分类为难愈性的溃疡愈合率为67%(75处溃疡中的50处)。原发性深静脉瓣膜功能不全相关溃疡的愈合率为76%,血栓形成后综合征相关溃疡的愈合率为58%(p = 0.08)。即使在复发的病例中(33%),这些溃疡也显著缩小,缩小幅度达原大小的80% - 90%。38%的移植区域出现感觉减退。对于因深静脉功能不全导致的“难愈性”下肢静脉溃疡,削痂疗法可产生良好的长期疗效。由于它只是一种对症治疗,不能减少病理性反流,因此小腿持续加压很重要。

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