Nicklasson F, Alderborn G
Department of Pharmacy, Uppsala University, Sweden.
Pharm Res. 2000 Aug;17(8):949-54. doi: 10.1023/a:1007575120817.
To analyze the mechanics of some pharmaceutical agglomerates during uniaxial confined compression by using compression parameters derived from the Heckel, Kawakita and Adams equations, and to study the influence of these compression parameters on the tablet-forming ability of agglomerates.
Force and displacement data sampled during in-die compression of agglomerates was used to calculate compression parameters according to the Heckel (sigmay), Kawakita (1/b and a), and Adams (tau0') equations. Mechanical strength of single agglomerates as well as the air permeability and tensile strength of tablets prepared from them were also determined.
Sigmay- from the Heckel equation did not differ between agglomerates of different porosity. Both 1/b and tau0' varied with agglomerate porosity and composition. These two compression parameters were linearly related to each other. No general correlation was found between 1/b and tau0' and the strength of single agglomerates. The two parameters were related to the intergranular pore structure and tensile strength of tablets formed from the agglomerates.
1/b and tau0' may be interpreted as measures of the agglomerate shear strength during uniaxial confined compression, and as such they may be used as indicators of the tabletting performance of the agglomerates.
通过使用从赫克尔方程、川北方程和亚当斯方程推导得出的压缩参数，分析一些药物团聚体在单轴受限压缩过程中的力学性能，并研究这些压缩参数对团聚体片剂成型能力的影响。
在模具内对团聚体进行压缩时采集的力和位移数据，用于根据赫克尔方程（σy）、川北方程（1/b和a）和亚当斯方程（τ0'）计算压缩参数。还测定了单个团聚体的机械强度以及由它们制备的片剂的透气率和拉伸强度。
不同孔隙率团聚体的赫克尔方程中的σy没有差异。1/b和τ0'均随团聚体孔隙率和组成而变化。这两个压缩参数彼此呈线性相关。未发现1/b和τ0'与单个团聚体强度之间存在普遍相关性。这两个参数与由团聚体制备的片剂的晶间孔隙结构和拉伸强度有关。
1/b和τ0'可被解释为单轴受限压缩过程中团聚体剪切强度的度量，因此它们可用作团聚体压片性能的指标。
