Nishida H, Nishiyama M
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
J Mol Evol. 2000 Sep;51(3):299-302. doi: 10.1007/s002390010091.
Recent finding that a prokaryote synthesizes lysine through the alpha-aminoadipate pathway demonstrates that the lysine synthesis through the alpha-aminoadipate pathway is not typical of fungi. However, the fungal lysine biosynthesis is not completely the same as the prokaryotic one. We point out that alpha-aminoadipate reductase is a key enzyme to the evolution of fungal lysine synthesis. In addition, fungi have two different saccharopine dehydrogenases, which is also characteristic of fungi.
最近的研究发现，一种原核生物通过α-氨基己二酸途径合成赖氨酸，这表明通过α-氨基己二酸途径合成赖氨酸并非真菌所特有。然而，真菌的赖氨酸生物合成与原核生物并不完全相同。我们指出，α-氨基己二酸还原酶是真菌赖氨酸合成进化的关键酶。此外，真菌有两种不同的酵母氨酸脱氢酶，这也是真菌的另一个特征。
