真菌中赖氨酸生物合成的α-氨基己二酸途径。

The alpha-aminoadipate pathway for lysine biosynthesis in fungi.

作者信息

Xu Hengyu, Andi Babak, Qian Jinghua, West Ann H, Cook Paul F

机构信息

Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73019, USA.

出版信息

Cell Biochem Biophys. 2006;46(1):43-64. doi: 10.1385/CBB:46:1:43.

DOI:10.1385/CBB:46:1:43

PMID:16943623

Abstract

This review provides a description of the biochemistry and enzymology of the alpha-aminoadipate pathway for lysine biosynthesis in fungi. The alpha-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.

摘要

本综述描述了真菌中赖氨酸生物合成的α-氨基己二酸途径的生物化学和酶学。α-氨基己二酸途径是真菌所特有的，因此是合理设计抗真菌药物的潜在靶点。文中介绍了该途径中七种酶的作用机制的现有知识，以及关于高柠檬酸合酶、酵母氨酸还原酶和酵母氨酸脱氢酶的结构和机制的详细信息。