Herpin T F, Van Kirk K G, Salvino J M, Yu S T, Labaudinière R F
Rhône-Poulenc Rorer Research and Development, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.
J Comb Chem. 2000 Sep-Oct;2(5):513-21. doi: 10.1021/cc000025u.
The solid-phase synthesis of a 10,000 member combinatorial library of 1,5-benzodiazepine-2-one derivatives is reported. The 3-amino-1,5-benzodiazepine-2-one scaffold was prepared in solution, and the benzamide nitrogen was used as a point of attachment to the resin. The 5-aniline and 3-amine were then used as points of diversity. A 10,000 member library was synthesized using the Irori directed sorting system, and after analysis of a representative sample from the library, the Irori system was used to remove the compounds of lower purity.
报道了1,5-苯二氮䓬-2-酮衍生物的10000成员组合库的固相合成。3-氨基-1,5-苯二氮䓬-2-酮支架在溶液中制备，苯甲酰胺氮用作连接到树脂的位点。然后将5-苯胺和3-胺用作多样性位点。使用Irori定向分选系统合成了一个10000成员的库，在对库中的代表性样品进行分析后，使用Irori系统去除纯度较低的化合物。
