Kamal Ahmed, Reddy K Laxma, Devaiah V, Shankaraiah N, Reddy D Rajasekhar
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India.
Mini Rev Med Chem. 2006 Jan;6(1):53-69. doi: 10.2174/138955706775197875.
Benzodiazepine based heterocycles can be prepared efficiently on solid-support by employing different approaches. In this review, an effort has been made to highlight academic and industrial examples of combinatorial synthesis for this type of heterocycles published in the last decade. Therefore, it describes synthetic strategies for the generation of benzodiazepine privileged structures employing the corresponding resin-bound substrates. Further, the most relevant biological properties of these heterocycles have also been incorporated.
基于苯二氮䓬的杂环化合物可以通过不同方法在固体载体上高效制备。在本综述中，我们努力突出过去十年发表的关于此类杂环化合物组合合成的学术和工业实例。因此，本文描述了利用相应的树脂结合底物生成苯二氮䓬优势结构的合成策略。此外，还纳入了这些杂环化合物最相关的生物学特性。
