Inoue H, Ito T, Siraki K, Sugimoto K, Sakai T, Oomori S, Takase K, Nakano T
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Int J Oncol. 2000 Nov;17(5):977-80. doi: 10.3892/ijo.17.5.977.
The effect of segmental transcatheter arterial chemoembolization (TAE) on serum amino acid levels and liver function were studied in 23 patients with HCC associated with hepatitis virus C (22 patients) or alcoholism (1 patient), with compensated liver cirrhosis (Child A 18 patients, Child B 5 patients). Serum levels of branched-chain amino acids (BCAA), tyrosine, branched-chain amino acids to tyrosine ratio (BTR), ammonia, total bilirubin and albumin, and prothrombin times were measured before and after TAE (24 h, 7 and 14 days). The BTR was increased significantly 24 h after TAE (p<0.001) and gradually decreased to pre-TAE levels. Serum tyrosine levels decreased at 24 h after TAE (p<0.005) and later increased. Serum BCAA levels increased slightly at 7days after TAE and were decreased at 14 days after TAE. This results indicated that the increased BTR was due primarily to the decreased tyrosine level at 24 h after TAE. Serum ammonia levels gradually decreased after TAE and the prothrombin time and serum levels of total bilirubin and albumin were not significantly changed. In this study, segmental TAE had little influence on liver function, and the BTR unexpectedly increased at 24 h after TAE. These results suggest that segmental TAE has minimal side effects and may have a beneficial effect on amino acid metabolism.
对23例伴有丙型肝炎病毒感染（22例）或酒精性肝病（1例）且有代偿期肝硬化（Child A级18例，Child B级5例）的肝癌患者，研究了节段性经导管动脉化疗栓塞术（TAE）对血清氨基酸水平和肝功能的影响。在TAE术前及术后（24小时、7天和14天）测定血清支链氨基酸（BCAA）、酪氨酸、支链氨基酸与酪氨酸比值（BTR）、氨、总胆红素、白蛋白水平以及凝血酶原时间。TAE术后24小时BTR显著升高（p<0.001），随后逐渐降至TAE术前水平。TAE术后24小时血清酪氨酸水平降低（p<0.005），之后升高。TAE术后7天血清BCAA水平略有升高，术后14天降低。这一结果表明，TAE术后24小时BTR升高主要是由于酪氨酸水平降低所致。TAE术后血清氨水平逐渐降低，凝血酶原时间以及总胆红素和白蛋白的血清水平无显著变化。在本研究中，节段性TAE对肝功能影响较小，且TAE术后24小时BTR意外升高。这些结果提示，节段性TAE副作用极小，可能对氨基酸代谢有有益作用。
