Kyle R A, Jowsey J, Kelly P J, Taves D R
N Engl J Med. 1975 Dec 25;293(26):1334-8. doi: 10.1056/NEJM197512252932602.
A randomized double-blind study was carried out in 26 patients with multiple myeloma to compare the therapeutic effect of sodium fluoride (50 mg twice daily) plus calcium carbonate (1 g four times daily) and placebo. All patients also received melphalan and prednisone for one week every six weeks. Bone biopsies for microradiography and histology, and videodensitometry as well as conventional roentgenograms, 99mTc-polyphosphate bone scans, and bone densitometry of the mid and distal radius, were done initially and one year after therapy. Microradiography and videodensitometry studies revealed significant increases in bone formation (P less than 0.01) and bone mass (P less than 0.005) in the fluoride-calcium group. Bone trabeculae appeared thickened on roentgenograms of six of 13 fluoride-calcium-treated patients (P less than 0.02). Technetium bone scans and bone densitometry determinations proved insensitive for detection of skeletal changes. Fluoride calcium should be considered a useful adjunct in the treatment for multiple myeloma.
对26例多发性骨髓瘤患者进行了一项随机双盲研究，以比较氟化钠（每日2次，每次50毫克）加碳酸钙（每日4次，每次1克）与安慰剂的治疗效果。所有患者每六周还接受一次马法兰和泼尼松治疗，为期一周。最初及治疗一年后，进行了用于显微放射摄影和组织学检查的骨活检、视频密度测定以及传统X线片、99m锝-多聚磷酸盐骨扫描和桡骨中远端骨密度测定。显微放射摄影和视频密度测定研究显示，氟钙组的骨形成（P<0.01）和骨量（P<0.005）显著增加。13例接受氟钙治疗的患者中有6例的X线片显示骨小梁增粗（P<0.02）。锝骨扫描和骨密度测定结果证明对检测骨骼变化不敏感。氟钙应被视为多发性骨髓瘤治疗中的一种有用辅助药物。
