Schilling A, Finkel H E
Arch Intern Med. 1975 Jan;135(1):193-6.
We reviewed the efficacy of three agents advocated as ancillary therapy in myeloma patients. Intramuscularly administered immune serum globulin (gamma globulin) was ineffective in preventing infection. Hemoglobin level was improved in some myeloma patients receiving androgens. However, the response rate and the degree of leukopenia or thrombocytopenia were not superior with androgen-melphalan-prenisone combination therapy, as compared with those resulting from the two-drug combination without androgen. A controlled study evaluating androgen plus melphalan has not been done. The long-term administration of fluoride, supplemented by calcium and androgen, induced radiologically apparent bone fluorosis, but strengthening of lytic bone was not observed. Neither objective nor subjective benefit was demonstrated in a controlled study comparing the effects of fluoride (without calcium supplement) with those of the placebo.
我们回顾了三种被倡导用于骨髓瘤患者辅助治疗的药物的疗效。肌肉注射免疫血清球蛋白（丙种球蛋白）在预防感染方面无效。一些接受雄激素治疗的骨髓瘤患者血红蛋白水平有所改善。然而，与不含雄激素的两药联合治疗相比，雄激素 - 美法仑 - 强的松联合治疗的缓解率以及白细胞减少或血小板减少的程度并无优势。尚未进行评估雄激素加美法仑的对照研究。长期补充钙和雄激素的同时给予氟化物会导致影像学上明显的骨氟中毒，但未观察到溶骨性骨病变强化。在一项比较氟化物（不补充钙）与安慰剂效果的对照研究中，未证明有客观或主观益处。
