Macchi L, Sarfati R, Guicheteau M, Chamlian V, Pourrat O, Gruel Y, Magnin G, Brizard A, Boinot C
Laboratoire d'Hématologie, CHU de Poitiers, France.
Clin Appl Thromb Hemost. 2000 Oct;6(4):187-9. doi: 10.1177/107602960000600401.
There is no consensus concerning thromboembolic prophylaxis in high-risk pregnant women with a previous history of heparin-induced thrombocytopenia. An alternative anticoagulant therapy is danaparoïd, whereas unfractioned and low-molecular-weight heparin therapy is contraindicated. We report a case of successful thrombosis prophylaxis using danaparoïd in a high-thrombosis-risk pregnant woman with a history of heparin-induced thrombocytopenia during a previous pregnancy and Widal's disease.
对于有肝素诱导的血小板减少症既往史的高危孕妇，血栓栓塞预防尚无共识。一种替代抗凝治疗药物是达那肝素，而普通肝素和低分子肝素治疗则属禁忌。我们报告了一例成功使用达那肝素预防血栓形成的病例，该孕妇既往有肝素诱导的血小板减少症病史，且曾患伤寒，本次妊娠血栓形成风险高。
