Klinger G, Glänzer S, Sigusch B, Klinger G, Römer W
Department of Conservative Dentistry, Faculty of Medicine, Friedrich Schiller University, Jena, Germany.
Pharmazie. 2000 Sep;55(9):678-80.
Clinical experience confirms the influence of sexual steroids on the periodont under several clinical conditions. The mechanisms of the noticed effects are not all completely understood. In this paper, phagocytes from gingival crevice fluid of 39 patients with different forms of periodontitis and 18 healthy persons without periodontal disease were examined. Phagocytic activity was assessed in vitro. Simultaneously to phagocytic examination, 17 beta-estradiol or dienogest were added to the samples in different concentrations, in order to see whether a difference existed between phagocytosis in the presence or absence of sexual steroids. Phagocytosis was significantly reduced in patients with periodontitis. It was found that phagocytosis was raised significantly by 13% in the group with periodontal disease under the influence of 17 beta-estradiol. The administration of dienogest did not change the phagocytosis capacity significantly. In the healthy group, neither addition of 17 beta-estradiol nor addition of dienogest caused any difference.
临床经验证实了性类固醇在多种临床情况下对牙周组织的影响。目前尚未完全了解所观察到的这些影响的机制。本文对39例不同类型牙周炎患者以及18例无牙周疾病的健康人的龈沟液中的吞噬细胞进行了检测。体外评估吞噬活性。在进行吞噬细胞检测的同时，向样本中添加不同浓度的17β-雌二醇或地诺孕素，以观察在有或没有性类固醇存在的情况下吞噬作用是否存在差异。牙周炎患者的吞噬作用明显降低。发现在17β-雌二醇的影响下，牙周疾病组的吞噬作用显著提高了13%。地诺孕素的使用并未显著改变吞噬能力。在健康组中，添加17β-雌二醇或地诺孕素均未引起任何差异。
