Lehotzky K
Fodor József Public Health Center, National Institute for Chemical Safety, Budapest, Hungary.
Acta Physiol Hung. 2000;87(1):67-70. doi: 10.1556/APhysiol.87.2000.1.7.
In order to establish safe exposure levels for toxic chemicals, risk assessment guidelines have been developed. A compilation is given by the author on the elements of risk assessment of hazardous neurotoxic pesticides, using data obtained from human epidemiological studies, from animal experiments, from the international literature and from the author's own experiments as well. Well-controlled laboratory studies of neurotoxicity have the potential to provide adequate exposure and effect data for accurate hazard identification. Animal models of neurotoxicity as highly sensitive behavioral and neurophysiological methods as a function of doses, provide data for human low dose extrapolation by using mathematical models. This procedure might be the basis for reducing risk ("risk management"), therefore some examples are given, how to handle properly neurotoxic pesticides with different- high or low-risk.
为了确定有毒化学品的安全暴露水平，已制定了风险评估指南。作者利用从人类流行病学研究、动物实验、国际文献以及作者自己的实验中获得的数据，对有害神经毒性农药的风险评估要素进行了汇编。神经毒性的严格对照实验室研究有潜力提供足够的暴露和效应数据，以进行准确的危害识别。作为剂量函数的高度敏感行为和神经生理方法的神经毒性动物模型，通过使用数学模型为人类低剂量外推提供数据。该程序可能是降低风险（“风险管理”）的基础，因此给出了一些如何妥善处理不同高风险或低风险神经毒性农药的例子。
