Jain S, Sehgal V N, Bajaj P
Skin Care Clinic, Darya Ganj, New Delhi, India.
J Eur Acad Dermatol Venereol. 2000 May;14(3):212-5. doi: 10.1046/j.1468-3083.2000.00066.x.
Nail changes in Langerhans cell histiocytosis are distinctly uncommon. Paronychial erythema, swelling and subungual pustules of the fingernails and toenails were cardinal, and were supported by diffuse as well as dense collections of mononuclear Langerhans cells evidenced by microscopic investigation. Oral administration of co-trimoxazole (800 mg sulphamethoxazole + 160 mg trimethoprim) every 12 h, 50 mg/d cyclophosphamide and 80 mg/d predinisolone were the mainstay of treatment, supported by scalp tar shampoo and local betamethasone lotion application.
朗格汉斯细胞组织细胞增多症中的指甲改变极为罕见。手指甲和脚趾甲的甲沟炎、红肿及甲下脓疱是主要表现，显微镜检查证实有弥漫性以及密集的单核朗格汉斯细胞聚集。治疗的主要方法是每12小时口服复方新诺明（800毫克磺胺甲恶唑 + 160毫克甲氧苄啶）、50毫克/天环磷酰胺和80毫克/天泼尼松龙，辅以头皮焦油洗发水和局部应用倍他米松洗剂。
