Timpatanapong P, Hathirat P, Isarangkura P
Arch Dermatol. 1984 Aug;120(8):1052-6.
A retrospective study of nail involvement was made in 15 cases of histiocytosis X (HX). These included seven cases of Letterer-Siwe (LS) disease, four cases of Hand-Schüller-Christian disease, and four cases of eosinophilic granuloma seen at Ramathibodi Hospital, Bangkok, Thailand, during the years 1970 to 1981. Nail involvement was found in three patients with LS disease, two of whom showed fingernail and toenail dystrophy with onycholysis and subungual hyperkeratosis. Paronychial erythema and swelling with small pustules underneath some nails were seen in both of the latter patients. The remaining patient showed subungual purpura of all fingernails and toenails with slight thickening of some fingernails. The nail changes in one patient responded well to cytotoxic therapy but recurred when the disease progressed. Nail involvement seems to be one of the unfavorable prognostic signs in HX.
对15例组织细胞增多症X（HX）患者的指甲受累情况进行了回顾性研究。这些病例包括1970年至1981年期间在泰国曼谷拉玛蒂博迪医院所见的7例勒-雪氏（LS）病、4例汉-许-克氏病和4例嗜酸性肉芽肿。在3例LS病患者中发现有指甲受累，其中2例表现为指甲和趾甲营养不良，伴有甲剥离和甲下角化过度。后2例患者均可见甲周红斑和肿胀，部分指甲下方有小脓疱。其余1例患者所有手指甲和趾甲均出现甲下紫癜，部分手指甲稍有增厚。1例患者的指甲改变对细胞毒性治疗反应良好，但病情进展时复发。指甲受累似乎是HX预后不良的体征之一。
