20K和22K人生长激素对大鼠水潴留作用的差异。

Differences in the effects of 20 K- and 22 K-hGH on water retention in rats.

作者信息

Satozawa N, Takezawa K, Miwa T, Takahashi S, Hayakawa M, Ooka H

机构信息

Medicinal Research Department, Institute of Biological Science, Mitsui Pharmaceuticals Inc., Chiba, Japan.

出版信息

Growth Horm IGF Res. 2000 Aug;10(4):187-92. doi: 10.1054/ghir.2000.0149.

DOI:10.1054/ghir.2000.0149

PMID:11032701

Abstract

Antidiuretic actions induced by two growth hormone (GH) isoforms (20 K- and 22 K-hGH; 0.2 and 2.0 mg/kg) were evaluated in rats, as fluid retention may cause oedema, one of the adverse effects of GH. Both GH isoforms (2.0 mg/kg) suppressed urine excretion in hypophysectomized rats (P< 0.01), but only the 22 K-hGH isoform (2.0 mg/kg) suppressed urine excretion in intact rats (P< 0.01). In addition, prolactin (PRL) suppressed urine excretion in intact rats (P< 0.05). In conclusion, 20 K-hGH has less potency in causing urine retention than 22 K-hGH and since 20 K-hGH is missing 15 amino acids found in 22 K-hGH, these amino acids may be important for the antidiuretic action of GH. Since prolactin suppressed urine excretion, a part of the antidiuretic action of GH may be related to PRL-R activation.

摘要

由于液体潴留可能导致水肿，而水肿是生长激素（GH）的不良反应之一，因此对两种生长激素亚型（20K-hGH和22K-hGH；0.2和2.0mg/kg）诱导的抗利尿作用在大鼠中进行了评估。两种生长激素亚型（2.0mg/kg）均抑制了垂体切除大鼠的尿液排泄（P<0.01），但只有22K-hGH亚型（2.0mg/kg）抑制了完整大鼠的尿液排泄（P<0.01）。此外，催乳素（PRL）抑制了完整大鼠的尿液排泄（P<0.05）。总之，20K-hGH导致尿液潴留的效力低于22K-hGH，并且由于20K-hGH缺少22K-hGH中发现的15个氨基酸，这些氨基酸可能对生长激素的抗利尿作用很重要。由于催乳素抑制了尿液排泄，生长激素的部分抗利尿作用可能与催乳素受体（PRL-R）激活有关。