Weibel L, Turek F W, Mocaer E, Van Reeth O
Centre d'Etudes des Rythmes Biologiques, School of Medicine, H opital Erasme, Université Libre de Bruxelles, Route de Lennik, 808, 1070, Brussels, Belgium.
Brain Res. 2000 Oct 13;880(1-2):207-11. doi: 10.1016/s0006-8993(00)02806-7.
Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by approximately 25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging.
