Yarus M, Welch M
Department of Molecular, Cellular and Developmental Biology, Universityof Colorado, Boulder 80309-0347, USA.
Chem Biol. 2000 Oct;7(10):R187-90. doi: 10.1016/s1074-5521(00)00027-2.
The finding that the universal ribosomal peptidyl transferase is an RNA enzyme casts new light on its ancient origins, on the use of transition state analogues for ribozymes, and on the role of selection-amplification in studies of molecular evolution.
普遍存在的核糖体肽基转移酶是一种RNA酶这一发现,为其古老起源、过渡态类似物在核酶中的应用以及选择扩增在分子进化研究中的作用带来了新的启示。